Oral communication abstractsObjectives: Chronic hypoxia is a powerful stimulus for the synthesis of erythropoietin (EPO) in the fetus resulting in an increase in erythrocyte production and in an increase in the oxygen-carrying capacity. We sought to describe the association between fetoplacental Doppler with cord blood EPO in small for gestational age (SGA) fetuses. Methods: A nested case-control study within a prospective cohort study including 124 controls (birthweight> p10) and 209 SGA cases (BW< p10). Cases an controls were followed-up with fetal biometry and fetoplacental Doppler. Cord blood concentrations of EPO were determined at delivery as a surrogate of chronic intrauterine hypoxia. Logistic regression predictive models evaluating the performance of fetal biometry and fetoplacental Doppler for the identification of chronic hypoxia were appraised. Results: Cord blood plasmatic EPO concentrations were significantly higher in SGA fetuses compared to controls (29.8 [17.2-58.7] vs 22.4 pg/mL [14.3-52.4],p = 0.05). In 87 (41.6%) of SGA fetuses, EPO was above 90 th centile. Among SGA fetuses, those with cord blood EPO concentrations above > 90 th centile presented non-significant differences in EFW centile [3 (1-9) vs 3 (1-8), p = 0.6] and ductus venosus z-score [0.11 (-0.91-0.95) vs. -0.33 (-0.95-0.56),p = 0.3], but higher uterine artery (UtA) z-score [1.42 (-0.58-2.95) vs 0.30 (-0.64-1.25),p = 0.01] and lower cerebroplacental (CPR) ratio z-score [
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.