We had reported previously on the synthesis and conversions of certain substituted pyrimidinyloximes of methyl aryl ketones [1]. Continuing our investigation of this series of compounds, we have now obtained new derivatives of 2-pyrimidinyland 6-pyrimidinylketoximes of the aliphatic series, and have studied their biological activity.By reactions of 2-chloro-4,6-dimethyl-and 2,4-dimethyl-6-chloropyrimidines with the sodium salts of oximes of aliphatic and alicyclic ketones in DMF, we obtained (Scheme 1) the corresponding O-(4,6-dimethyl-2-pyrimidinyl)ketoximes (Ia,c-f) and O-(2,4-dimethyl-6-pyrimidinyl)ketoximes (IIa-e). By the interaction of 2-methyl-4,6-dichloropyrimidine with the sodium salts of the oximes of acetone and methyl ethyl ketone, we obtained with high yields either monosubstimted products, namely O-(2-methyl-4-chloro-6-pyrimidinyl)ketoximes (III) (Scheme 2) (at room temperature with a 1:1 reactant ratio), or the bis-adduct, in this case when the dichloropyrimidine was heated with a threefold excess of the salt of acetone oxime.Erevan Institute of the National Economy, Erevan 375025. M. V. Lomonosov
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