Famotidine is a member of H 2 -receptor antagonist drug, which pharmacological action primarily involves antagonism of the action of histamine at its H 2 -receptors. The incompatibility between famotidine and some commonly used tablet excipients was studied. The investigation was made on Avicel PH 105, Emcocel 90, starch 1500 (Sta-Rx 1500), Emdex, sorbitol, mannitol, cross linked sodium carboxymethylcellulose (Ac-Di-sol), PEG6000, hydroxyethylcellulose (HEC) (natrosol) and saccharin sodium. The investigation is made by DSC, IR and X-ray diffraction analysis. The DSC analysis indicated that there was no interaction between famotidine with Emcocel 90, Avicel PH 105, starch 1500, Ac-Di-sol, mannitol, HEC (natrosol) and saccharin sodium. On the other hand DSC indicated an incompatibility between famotidine and sorbitol, Emdex and PEG6000. The study of IR indicated the interaction between famotidine and PEG6000. X-ray diffraction study was carried out on excipients that showed possible interaction with famotidine during the DSC investigations. Only interaction between famotidine, Emdex and PEG6000 was confirmed.
The aim of this study was to evaluate compatibility and stability of the maximum concentration used for binary admixture containing dobutamine and dopamine in 5% glucose. The maximum concentration of each drug was 5.76 mg/ml of dobutamine and 2.88 mg/ml of dopamine in 50 ml of 5% glucose. The physical compatibility of binary admixtures was assessed using visual inspection and pH determination immediately after preparation (at 0 time) and after 24 hrs. The chemical stability was assessed using high performance thin layer chromatoghraphy (HPTLC). The method is based on HPTLC separation of the two drugs followed by densitometric measurements of their spots at 254 nm using Camag TLC Scanner 3. The mobile phase comprised ethyl acetate : n-propanol : water : glecial acetic acid (60:24:9:3, v/v/v/v). The results revealed that no precipitation, gas evaluation, color change, pH change or chemical incompatibility were observed over the entire time of mixing of two drugs in 5% glucose solution.
The aim of this study was to evaluate compatibility and stability of the maximum concentration used for ternary admixture containing midazolam, dobutamine and dopamine in 5% glucose and 0.9% sodium chloride solutions. The maximum concentration of each drug was 0.144 mg/ml of midazolam, 5.76 mg/ml of dobutamine and 2.88 mg/ml of dopamine in 50 ml of 5% glucose or 0.9% sodium chloride solutions. The physical compatibility of ternary admixtures was assessed using visual inspection and pH determination of ternary admixtures immediately after preparation (at 0 time) and after 24 hrs. The chemical stability was assessed using high performance thin layer chromatoghraphy (HPTLC). The method is based on HPTLC separation of the three drugs followed by densitometric measurements of their spots at 254 nm using Camag TLC Scanner 3. The mobile phase comprised ethyl acetate : n-propanol : water : glecial acetic acid (60:24:9:3, v/v/v/v). There were no visual changes (such as precipitation, gas evaluation or change in color) during 24 hrs after preparation of admixture. Also, there was no change in pH values of admixtures during that time. The results revealed chemical stability of midazolam, dobutamine and dopamine over the duration of mixing (24 hrs) in 5% glucose or 0.9% sodium chloride solutions.
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