Despite recent developments in intensive care, sepsis remains one of the leading problems faced by clinicians involved in the field. Sepsis is the cause of approximately 34.0% and 37.4% admissions to Polish and European intensive care units (ICU), respectively, and it is associated with very high mortality, reaching 32.2% among patients with severe sepsis [1, 2]. Alarmingly, there is an upward trend in its prevalence and mortality rate worldwide [3]. Furthermore, sepsis is a crucial issue for the policymakers, due to the high cost of ICU treatment, estimated to be $27,461 per case, and the significant re-hospitalisation rate among sepsis survivors, reaching 63% [4, 5]. Considering the aforementioned data, precise and reliable predictive factors in sepsis are needed. However, the search for further prognostic biomarkers is ongoing. Sepsis is associated with dysfunction of multiple organs. Respiratory failure, hypotension, and/ or shock contribute to hypoxia, thus reducing the

Fadrozole -a non-steroidal aromatase inhibitor was applied to common carp and goldfish to examine its ability to potentiate the stimulatory action of GnRH analogues on LH secretion in vivo. The goal of the project was to find a substitute for antidopaminergic drugs used with GnRH analogues in fisheries practice to stimulate ovulation in fish bred in captivity. The first trials on goldfish showed a moderate ability of fadrozole to potentiate salmon GnRH analogue stimulation, weaker than that obtained with pimozide (dopamine antagonist). No ovulation in fadrozole-treated fish was observed. Several experiments performed in two consecutive reproductive seasons (different treatment regimes and doses of fadrozole) neither improved nor confirmed the results obtained in the first year. The analysis of 17β-estradiol levels in the blood plasma and in hypothalami showed no changes in the concentration of this steroid in fadrozole-treated fish in comparison with the controls. This shows that fadrozole is not able to replace the antidopaminergic drugs used in fisheries practice and cannot be considered as a potential ovulation inducer in cyprinids.