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Aims: Nilavembu kudineer chooranam is one of the best polyherbal formulations in Siddha tradition of medicinal practice. This formulation has nine herbs as ingredients. This research article explores the scientific analysis of the therapeutic and phytochemical potential of this herbal formulation. Methodology: In this study, Nilavembu Kudineer Chooranam is extracted with hot ethyl acetate using a Soxhlet apparatus. This study focuses on the pharmacognosy, phytochemistry, physico-chemistry TLC analysis and antioxidant ability of Nilavembu Kudineer chooranam. High-performance thin-layer chromatography (HPTLC) is used to analyze the extract of Nilavembu Kudineer Chooranam to screen for active principles. Antioxidant activity of Nilavembu Kudineer Chooranam was determined using DPPH assay. Gas Chromatogram Mass Spectrometric method (GCMS) was carried out in the ethyl acetate extract of NKC for phytochemical analysis. Results: The preliminary phytochemical analysis of the ethyl acetate extract of Nilavembu Kudineer Chooranam reveals the presence of phytochemicals. The quantitative phytochemical estimations show the presence of 0.082 mg of alkaloid, 5.81 mg of flavanoid, 4.32 mg of tannin and 0.736 mg of phenolics in ethyl acetate extract. The HPTLC analysis confirmed the presence of such phytochemicals that are well known for their medicinal properties. The percentage of moisture content, total Ash, acid-soluble ash, and a water-soluble ash content of NKC were found to be 3.7%, 9.07%,1.66%, and 0.75% respectively. The fluorescence analysis of NKC powder with different chemical reagents revealed the presence of several active principles in the extract. The antioxidant ability of NKC extract was also assessed by FACS analysis using DCFDA assay in THP-I (human monocyte) cells. Conclusion: In this in-vitro assay NKC extract significantly reduced the intracellular antioxidant levels in THP-I cells.  Thus the in-vitro assay further confirmed the antioxidant potential of NKC extract. It is apparent from the above results and discoveries that NKC makes a perfect health drink.

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Far back since the existence of the human race, plant species have been used as herb or medicine to either treat, suppress or cure the human numerous sicknesses. This poses the truth that green medicine is safe, cost-efficient, and effective with little or no side effects. Up-till date, the medicinal plant has gained world attraction which has led to global development and discovery of new drug formulations. The beneficial features of plant medicine are enormous and should not be under-estimated. However, in this study, Abrus precatorius Linn., an alternative to Glycyrrhiza glabra has been extensively reviewed to expose this herb secret to the scientific research world for the development of possible novel drug formulations in response to the present global diseases around the globe.

Objective: Nilavembu Kudineer Chooranam is the combination of nine plant materials. The nine components are Nilavempu (Andrographis paniculata), Vettiver (Vetiveria zizanioides), Vilamiccamver (plectranthus vettiveroides), Santanam (Santalum album), Peyputtal (Trichosanthes dioica), Koraikkilanku (Cyperus rotandus), Cukku (Zingeber officinale), Milaku (Piper nigrum), Parpatakam (Mollugo cerviana). All these plants are used conventionally in the treatment of fever, inflammation, arthralgia, arthritis, gastric ulcer, jaundice, and general weaknes Methods: About 500gm of dried fine powder of Santalum album were soaked in the extractor and macerated for 30 hrs with petroleum ether. On the 22ndday after overnight fast the blood was collected from retro- orbital After the separation of serum from the blood assay of ALT, AST, ALP, γGT and bilirubin were done using standard methods and enzyme assay tests. Results: The preliminary phytochemical analysis of the Chloroform extract of Santalum album reveals the presence of alkaloid, flavonoid, phenol, coumarin, and tannin. The pretreatment of chloroform extract of Santalum album at a dose of 200mg and 400mg/kg (group IV and V) appeared to significantly prevent the galactosamine toxicity as revealed by the hepatic cells which were preserved in cytoplasms. Conclusion: Our findings demonstrated that chloroform extract of Santalum album at both doses possesses hepatoprotective and antioxidant activity, which is evidenced by lowered serum hepatic marker enzyme activities. Among the two dosages tested, 400 mg/kg/body weight showed more promising hepatoprotective and antioxidant activity, and is comparable to the standard drug Silymarin. Keywords: Nilavembu Kudineer Chooranam, Chloroform extract of Santalum album, preliminary phytochemical analysis, Hepatoprotective activity, D-Galactosamine induced hepatotoxicity in rats.