BackgroundPrenatal life exposures, potentially manifested as altered birth size, may influence the later risk of major chronic diseases through direct biologic effects on disease processes, but also by modifying adult behaviors such as physical activity that may influence later disease risk.Methods/Principal FindingsWe investigated the association between birth weight and leisure time physical activity (LTPA) in 43,482 adolescents and adults from 13 Nordic cohorts. Random effects meta-analyses were performed on categorical estimates from cohort-, age-, sex- and birth weight specific analyses. Birth weight showed a reverse U-shaped association with later LTPA; within the range of normal weight the association was negligible but weights below and above this range were associated with a lower probability of undertaking LTPA. Compared with the reference category (3.26–3.75 kg), the birth weight categories of 1.26–1.75, 1.76–2.25, 2.26–2.75, and 4.76–5.25 kg, had odds ratios of 0.67 (95% confidence interval: 0.47, 0.94), 0.72 (0.59, 0.88), 0.89 (0.79, 0.99), and 0.65 (0.50, 0.86), respectively. The shape and strength of the birth weight-LTPA association was virtually independent of sex, age, gestational age, educational level, concurrent body mass index, and smoking.Conclusions/SignificanceThe association between birth weight and undertaking LTPA is very weak within the normal birth weight range, but both low and high birth weights are associated with a lower probability of undertaking LTPA, which hence may be a mediator between prenatal influences and later disease risk.

The aims of this study were to examine the genetic contribution on physical activity (PA) within a nationwide population of young adult male twin pairs from Sweden and to investigate the equal environment assumption (EEA) in relation to PA. Information on PA was collected by questionnaires in 1998 and 2002 and the impact of genetic factors was estimated by structural equation modeling (SEM). The study included 1,022 pairs of twins and the best fitting SEM-model gave a heritability of 49% (95% CI, 40-56%) for total PA and all PA dimensions showed genetic contributions between 40% and 65%. Non-shared environmental factors were also important, whereas shared environmental factors did not contribute to PA behaviors. The EEA was investigated with a linear regression model, examining if the twins contact frequency predicted within-pair differences in PA, and further by a simulation study. We found no support for violation of the EEA.

Objective: To assess the size of biases in self-reported height, weight in a large sample of adolescents with special attention to possible effects of body dissatisfaction and to assess how such biases may influence estimates of overweight and obesity. Design: Cross-sectional study. Setting: Unselected population from Southwestern parts of Stockholm County, Sweden. Subjects: Two-thousand seven hundred and twenty-six boys and girls, 15 years of age. Methods: Data were collected by a questionnaire answered by adolescents and a physical examination made by trained study nurses. A validated physical appearance scale and body silhouettes were embedded into the questionnaire. Results: Obese boys under-reported their weight (5.2 kg) (95% confidence intervals (CI) 3.7; 6.6) more than obese girls (3.8 kg) (95% CI 1.8; 5.8). Agreement between self-reported and measured body mass index (BMI)-categories (obese, overweight and non-overweight/obese) as estimated by weighted kappa was 0.77 (95% CI 0.72; 0.82) for girls and 0.74 (95% CI 0.70; 0.79) for boys. For obese girls and boys sensitivity of self-reports were 0.65 (95% CI 0.47; 0.79) and 0.52 (95% CI 0.38; 0.66). Boys with low scores on the physical appearance scale under-reported their weight and BMI more than those with high scores. Boys and girls who wished to be leaner under-reported their weight and BMI more than subjects who were satisfied with their body size (Po0.05). Conclusion: Thirty-five percent of obese girls and 48% of obese boys would remain undetected from self-reported data. Boys and girls who were dissatisfied with their physical appearance or size under-reported their weight more than satisfied subjects.

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