Introduction Idiopathic scoliosis is associated with severe spinal deformity, and prediction of scoliosis progression is important in the early stages for prevention and treatment. The objective was to identify the relationship between the serotonin blood level in children and adolescents aged 4 to 15 years and progressing scoliosis grades I-II over a five-year period. Material and methods Eighty-six children and adolescents with impaired posture and scoliosis were assigned to 3 groups according to clinical and radiological data and the serotonin level, the course of scoliosis, and the parameters were measured during 5 years. Results A significant increase in the medians, interquartile intervals of serotonin levels and the curve angle was observed in the group of progressive scoliosis with higher rates seen in girls. Significant differences in the serotonin serum level were observed in the groups. Correlation analysis showed a weak relationship between the serotonin level and the curve evaluated radiologically in patients with non‑progressive scoliosis with an increase in the relationship to moderate in the progression group at 5 years. The analysis of the diagnostic efficiency of the serotonin blood level in patients with different course of scoliosis revealed the good quality of the prognostic test. Discussion The serotonin serum level had a statistically significant relationship with the progression of the curve examined radiologically. Conclusion A laboratory marker indicating progression of the curvature in children and adolescents with idiopathic scoliosis was identified. The marker included an increased serotonin blood level of greater than 270 ng/ml. The marker appeared to be practical because it could 1) be measured in the blood of children and adolescents; 2) show the dynamics in the increased serotonin level correlating with radiographic findings of the spine; and 3) indicate to the neurohumoral state of a growing body with the pathology under study. The serotonin blood level can be a marker of progressive scoliosis. The findings have been protected by an invention patent.
This article discusses the issues of studying the dynamics of changes in serotonin in biological fluids as a marker in various neuro-orthopedic diseases in patients of different ages. For this, an analysis of clinical practice has been carried out. It is concluded that changes in serotonin levels can be considered as an indicator of pain sensations and control of ongoing therapy in neuro-orthopedic pathologies. The need for a further indepth study of the existing practice of assessing changes in the level of serotonin in biological fluids during conservative treatment and after surgery in various cases of neuro-orthopedic diseases in patients of different ages is indicated.
The article reflects topical issues of natal trauma and its consequences in children born surgically, with a comparison of different views of domestic and foreign scientists. Risk factors for natal trauma, features of the caesarean section technique, options for complications and outcomes for the newborn are presented. Data from a study of the health of 93 children aged 1 to 16 years who were born surgically by caesarean section were analyzed, approaches to the occurrence of natal trauma and its consequences, as well as their diagnosis and treatment in pediatric patients were considered. It is concluded that the treatment of natal trauma and its consequences after operative delivery should be aimed at eliminating the causes and undesirable symptoms of birth trauma.
216 children and adolescents from 3 months to 17 years with mild neuroorthopedic pathology – torticollis, abnormal foot placement, flat-valgus feet, posture disorders, scoliosis, shortening of the limb were examined. The etiological factors of Natal trauma and the pathogenesis of torticollis formation were determined with confirmation by instrumental research methods. During the growth of the child, there is a progression of neuroorthopedic pathology in the form of scoliotic spinal deformity with a misalignment of the pelvic bones due to an asymmetric flat-valgus installation of the feet. The program for differential diagnosis and prevention of mild neuroorthopedic disorders was developed depending on the age of children. It is shown, that the leading link in the pathogenesis of neuroorthopedic pathology is natal trauma. Timely diagnosis, treatment and prevention of disorders of the musculoskeletal system will prevent the formation of pathology in various age periods.
e. Imbalance of hormones in a woman's body provokes a number of disorders of the body's functions, which affects her emotional and physical well-being. Purpose – to study the current state of the problem of changes in the musculo-ligamentous apparatus in pregnant women against the background of changes in their hormonal status. Material and methods. A systematic analysis of the main hormonal changes occurring in a woman's body during childbearing, and the results of research by Russian and foreign experts in this area. Results and discussion. It has been established that to date, in Russian and foreign practice, the number of studies that show the correlation between changes in the hormonal background of a pregnant woman and her musculo-ligamentous apparatus is still insignificant and is extremely fragmented. Conclusion. It is concluded that it is necessary to expand the boundaries of experimental studies and conduct a detailed analysis of clinical cases of the onset and exacerbation of musculo-ligamentous pathologies in a situation of a change in the hormonal status of a woman against the background of her pregnancy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.