The search for novel antibiotics is of immense importance in research areas around the world for agricultural, pharmaceutical, and industrial applications. The s-triazines are widely used as an important biological tool for the production of a wide range of novel secondary metabolites. In the present study, the series of 1-substituted-(2H)-2-thio-4-(3- substitutedthiocarbamido-1-yl)-6-(2-imino-4-thio- 5- substitutedbiureto-1-yl) 1,2-dihydro-s-triazine [4a(i) to 4f(iii)] have been obtained by the isomerisation of 2-(2-imino-4-thio-5- substitutedbiureto-1-yl)-4-(3- substitutedthio-carbamido-1-yl)-6- substitutedimino-1,3,5-thiadiazine [3a(i) to 3f(iii)] in presence of ethanolic sodium bicarbonate solution. The later were synthesized by the chemical action of 1, 3-bis-(N-phenylamidinothiocarbamido)-thiocarbamide and aryl/alkylisocyanodichlorides. On the basis of IR, PMR spectrum data and elemental analysis, the structures of all these compounds were established. The synthesized s-triazine were analyzed for antimicrobial activities by cup plate diffusion method and exhibited a broad spectrum of antimicrobial activity against test pathogens. The isolate was tested for the ability to grow in the presence of antibiotic, such as ciprofloxacin at the same concentration. Thus, the study concludes with the eco-friendly route for synthesizing s-triazine with antibacterial activity against clinically important pathogens.
Amidinothiocarbamides and their derivatives possess various pharmaceutical, industrial, medicinal and agricultural values [1][2][3][4] . Intraction of different thiocarbamides and substituted cyanamides were carried out to synthesised respective substituted thiocarbamides, bis-foramidino sulphide, amidinothiocarbamides (salt) and their derivatives. [5][6][7][8] Amidinothiocarbamides and their derivatives were successfully cyclised into respective Hector's bases, thiadiazines, dithiazines, thiadiazolidines, s-triazines and pyrimidines by using different reagent and different reaction conditions. [9][10][11][12][13][14] So it was thought interesting to synthesis yet new series of 1,3-bis (Nsubstitutedamidinothiocarbamido)-thiocarbamides.(2) which may posses different pharmaceutical, industrial, medicinal, agricultural important which may be further cyclise to synthesis yet new series of 5 and 6 membered hetercyclic compounds.The structure of all these compounds were established on the basis of elemental analysis ,IR and PMR spectral data.
Amidinothiocarbamides and their derivatives possess various pharmaceutical, industrial, medicinal and agricultural values. Intraction of different thiocarbamides and substituted cyanamides were carried out to synthesised respective substituted thiocarbamides, bisforamidino sulphide, amidinothiocarbamides (salt) and their derivatives. Amidinothiocarbamides and their derivatives were successfully cyclised into respective Hector's bases, thiadiazines, dithiazines, thiadiazolidines, s-triazines and pyrimidines by using different reagent and different reaction conditions. So it was thought interesting to study of their antimicrobial activities by cup plate diffusion method to obtained new series of effective drugs. These compounds were screened against E.coli, S.typhi, A.aerogenes, S.aureus, and B.subtilis human pathogen. These compound shows effective drugs effect in medicinal and agricultural fields.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.