Of 270 patients who had a cone biopsy of the cervix, 50 subsequently achieved a total of 68 pregnancies. The outcome of these pregnancies is described.
Correspondence BRITISH MEDICAL JOURNAL difficult exchange transfusion. In the first of these two cases there was a positive blood culture for E. coli associated with bowel necrosis extending from the caecum to the descending colon. Our second case had diarrhoea for seven days, which preceded the onset of abdominal distension and peripheral circulatory collapse owing to necrosis and perforation of the terminal ileum only. Unfortunately both these infants died without laparotomy being undertaken, and at necropsy we were able to demonstrate antemortem thrombi in the ductus venosus and portal vein in the first and in the portal and splenic veins in the second. We note that in the series quoted there is no comment on the state of the portal vein in those infants who died. A fuller report is being prepared for publication.-We are, etc., E.
Summary
During the years 1952–1977, 646 patients with abnormal cervical cytology underwent cone biopsy (595) or ring biopsy of the cervix. The histological diagnoses were invasive carcinoma 20 (3%) microinvasive carcinoma 16 (2%), carcinoma in situ and severe dysplasia 418 (65 %), other dysplasias 149 (23 %). The remainder, 43 (7%) had no demonstrable abnormality. Following biopsy 41 (7%) patients with non‐invasive disease had abnormal cytology within a year of biopsy. A further 12 (2%) developed abnormal cytology after one year. These recurrences occurred up to 12 years after the initial treatment, and in one patient invasive squamous carcinoma has developed.
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