The optimized ¹³C-mixed triglyceride breath test is an accurate and simple breath test for the diagnosis of PEI in patients with CP, easily applicable to the clinical routine.

Introduction: This study assessed the feasibility, performance, and safety of Mirasol®-treated platelet concentrates (M-PC) stored for up to 7 days. Methods: This prospective observational study was approved by the ethical committee of the University Clinic of Santiago de Compostela. Informed consent was asked from patients receiving M-PC. M-PCs were treated with the Mirasol system according to the manufacturer's instructions. Thrombocytopenic patients were transfused according to the Spanish transfusion guidelines. Post-transfusion platelet counts were measured at 1 h and/or 24 h after transfusion. Post-transfusion surveillance of patients was maintained during the study. Results: Data from 54 evaluable patients and 135 transfusions were analyzed. The mean age of patients was 58 years. The mean age of M-PC at transfusion was 3.6 days. The mean platelet dose was 3.7 × 10¹¹. The transfusion responses measured as mean corrected count increment 1 h after transfusion (CCI_1h) and CCI_24h were 9,659 and 4,751, respectively. 65% of transfusions resulted in CCI_1h values ≥ 7,500. 51% of transfusions resulted in CCI_24h values ≥ 4,500. Conclusion: The use of M-PC in the supportive treatment proved to be safe and effective for this cohort of thrombocytopenic patients.

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