One hundred sixty‐one patients with postoperative pain were treated at a single center in a double‐blind, randomized, parallei study designed to compare the efficacy and safety of single oral doses of ketoprofen (50 and 150 mg), an acetaminophen (650 mg) plus codeine (60 mg) combination, and placebo. From 1 through 4 hours after administration of the study drugs, the mean summed pain intensity difference (SPID) and time‐weighted total pain relief (TOPAR) scores for the three active treatments generally were significantly (P < 0.05) higher than those for placebo but not significantly different from each other. At the 6‐hour evaluation, the ketoprofen groups, but not the acetaminophen‐codeine group, had higher (P < 0.05) mean SPID and TOPAR scores than the placebo group, as a result of a shorter duration of pain relief in the acetaminophen‐codeine group. The 6‐hour TOPAR scores were significantly (P < 0.05) higher for both ketoprofen groups than for the acetaminophen‐codeine group; the ketoprofen 150 mg group also had significantly (P < 0.05) higher mean 6‐hour SPID and global subjective assessment scores. As a result of a higher frequency of somnolence, there was a significantly (P < 0.05) greater incidence of central nervous system adverse drug reactions among patients treated with acetaminophen pius codeine than among those treated with 150 mg of ketoprofen. These results indicate that the analgesic efficacy of both 50 and 150 mg doses of ketoprofen equals that of acetaminophen 650 mg plus codeine 60 mg and the duration of the analgesic effect of ketoprofen is significantly longer.
Eighty-eight patients with moderate or severe postoperative pain were entered into a double-blind, single-injection trial designed to assess the analgesic efficacy of intramuscular zomepirac 100 mg. Patients were randomly selected to receive zomepirac injection, meperidine 100 mg or meperidine 50 mg. By most criteria of analgesic efficacy, zomepirac was superior to meperidine 50 mg and as effective as meperidine 100 mg. In terms of peak analgesia (and of patients' global evaluations), both meperidine 100 mg and zomepirac were superior to meperidine 50 mg. Total analgesia provided by zomepirac was greater than that with meperidine 100 mg, which was greater than that with meperidine 50 mg. Significantly fewer patients needed remedication during the observation period, and mean time to remedication was significantly longer for the zomepirac group than for either meperidine group. No serious adverse effects were reported.
The management of severe pain is a challenge to the entire medical team, and in the hospital setting the nurse's role is vital because he or she often serves as the corrununicative link between the patient and the physician.While giving the sympathetic and tender care that is part of our training, the nurse monitors and observes the patient, relays important information to the physician that will make the patient's care more effective, and is responsible for treatment compliance.This traditional role of the nurse in the management of pain is one that we all understand and relate to, but a new nursing role has developed in which nurses are contributing in a broader sense to a better understanding of pain and to the availability and delivery of more effective analgesics. This new speciality, that of the analgesic study nurse or nurse observer, demands skills and orientation that, in many ways, differ from those of the traditional nurse's role.she bring to the job? the study nurse is the person solely responsible for the conduct of the study.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.