Background and Aims:Little is known about the extent of mitochondrial respiratory chain (MRC) activity dysfunction in patients with alcoholic hepatitis (AH). We aimed to assess the hepatic MRC activity in AH patients and its potential impact on the severity and prognosis of this life-threatening liver disease.Methods: MRC complexes were measured in liver biopsies of 98 AH patients (nonsevere, 17; severe, 81) and in 12 histologically normal livers (NL). Severity was assessed according to Maddrey's Index and MELD score. Corticosteroid response rate and cumulative mortality were also evaluated.
On the first day of admission, ultrasound measurement of the RI of the interlobar arteries recognizes with high predictive accuracy those cirrhotic patients admitted with AD who will develop ACLF during hospital admission.
LINKED CONTENTThis article is linked to Solís‐Muñoz et al papers. To view these articles, visit https://doi.org/10.1111/apt.17434 and https://doi.org/10.1111/apt.17440
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