Non-small-cell lung cancer (NSCLC) is considered one of the most chemoresistant tumours, and in a recent overview the pessimism about the absolute survival benefits from chemotherapy was underlined (Non-small Cell Lung Cancer Collaborative Group, 1995). In particular, the meta-analysis revealed a survival benefit of 10% at 1 year in a supportive care setting and an increased median survival of 1.5 months in patients treated with platinum-based chemotherapy regimens, thus emphasizing the need for new, effective drugs and drug combination regimens.Phase I-II clinical studies have shown that new drugs such as gemcitabine and taxanes, used singly
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