Background: Opioids are the corner stone for perioperative analgesia in major surgeries. The aim of this study was to compare the efficacy of preventive multimodal analgesia versus morphine on post-operative pain and total morphine consumption. Aim of Study: To compare the efficacy of preventive multimodal analgesia versus morphine in cancer patients undergoing major abdominal surgeries. Patients and Methods: This prospective randomized study was done from March 2018 to September 2018 after approval of the institutional board review of National Cancer Institute. Forty cancer patients were randomly allocated in the study; patients were divided into 2 groups; multimodal group (n=20) received Ketamine, magnesium, ketorolac, paracetamol, with TAB (transverse abdominis plane) block before surgical incision and morphine group (n=20) received morphine sulphate 0.1mg/kg before surgical incision. Results: There was statistically significant difference in intraoperative fentanyl consumption p-value (<0.001) and total morphine consumption in the first 24 hours postoperatively p-value (0.001) between the 2 studied groups being higher in the morphine group. Conclusion: Preventive multimodal analgesia has superior analgesic profile than morphine regarding perioperative analgesia and morphine consumption in the first 24 hours post-operatively.