Background: Sinonasal lesions are a common finding in Otorhinolaryngology out patient department. Most commonly they present withnasal obstruction. Clinically many of these lesions resemble eachother but they have multiple differential d iagnosis ranging from congenital, inflammatory, trau matic to neoplastic causes that needs histopathological confirmat ion. Objecti ves: This study was undertaken to study the various histopathological patterns of sino-nasallesions, theirclassification and relat ive distribution of various lesions with regard to age and sex in our setting. Material and Methods: This was a retrospective study of Sino-nasal lesions specimens thatwas received at histopathology section of Depart ment of Pathology, Hamdard Institute of Medical Science andResearch andover a period of two years fro m June 2014 to May 2016. Results: A total of 62 cases of sino-nasal lesions were reported during the study period. Ageranged fro m 5 years to 75 years with malepredo minance. Among all the lesions forty five (45) were non-neoplastic, ten (10) benign and seven (7) were diagnosedas malignant tumors. Inflammatory polyp was the commonest non-neoplastic lesion while Sinonasal Papillo ma was the commonest benign lesion and Sinonasal carcinoma was themost common malignancy. Conclusions: Sino-nasal lesions comprises of wide spectrum of lesions but their presenting clin icalmanifestations are very limited. Hence, on the basis of clinical picture various nonneoplastic, benign and malignantlesions may mimic each other. Histopathological diagnosis forms the mainstay of diagnosis in these lesions which may even reveal clinically unsuspected rare malignancies as seen in our study.
Inflammatory pseudotumors (IPTs) of the spleen are extremely rare, benign tumors of unknown etiology, and are most frequently detected incidentally. We report a case of IPT of the spleen in a 19-year-old male, who presented to the Hamdard Institute of Medical Sciences and Research, New Delhi, with a history of pain and heaviness in the left hypochondrium. On clinical examination, splenomegaly was detected. Ultrasonography and contrast-enhanced computed tomography of the abdomen revealed an enlarged spleen with a mass lesion completely occupying the lower pole of the spleen. Therefore, a diagnosis of splenomegaly with a malignant splenic lesion was suggested. Open splenectomy was performed. On gross examination, a well-circumscribed nodular growth measuring 9 × 8 × 5 cm in diameter was seen on the lower pole of the spleen, which on cut section appeared tan white with foci of yellowish discoloration. Microscopic examination of the nodular growth revealed spindle cells in a hyalinized stroma with inflammatory infiltration of predominantly plasma cells and lymphocytes. On immunohistochemistry, the spindle cells were positive for smooth muscle actin. A diagnosis of IPT of the spleen was rendered following histopathology testing. Splenectomy is both diagnostic and curative for this rare entity, and prognosis is usually favorable following the procedure.
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