The sFlt-1/PlGF ratio test has the potential to improve clinical decision-making and allocation of scarce resources by reducing unnecessary hospitalization of women at low risk of developing pre-eclampsia, and ensuring that women at higher risk are identified and managed appropriately.

A923from an official publication of the Ministry of Health. A sensitivity analysis of 1000 simulations was performed on both outcome variables and costs through a Monte Carlo model using gamma distributions. Results: Nutrition care interventions targeting hospitalized at-risk and malnourished patients could contribute to cost savings of US $503.3 million ($1.5 billion COP) annually. Additionally, reduction of unplanned readmissions contributes to cost savings of US $77.1 million ($230.000 COP million) per year, while rationalization of hospital diets and wasting contributes to cost savings of US $1.3 million ($ 3.900 million COP) per year. This translates into total savings of US $580.4 million (1.7 billion COP), which represents the cost needed to attend 10% of inpatients admitted to Colombian hospitals in one year. ConClusions: Nutrition care interventions targeting at-risk and malnourished hospitalized patients can generate significant cost savings for the Colombian health care system as a result of reducing patient hospital length of stay, cost per event, unplanned hospital readmissions, rationalizing hospital diets, and increasing the capability of hospital beds utilization without having to incur additional investment expenses.

A865 of the Mexican population, that is the reason why the institution must consider alternatives that bring not only effectiveness, instead "value for money" due to cost cuttings and containment issues experienced during the last years. Methods: The cost model considered population covered by the Mexican Institute of Social Security (IMSS), in this sense the target population (base case scenario) was chosen based on those patients with DT1 diagnosed and treated, in order to model the budget impact with and without the intervention. We conducted a pragmatic literature review and treatment comparison to find out hypoglycemic events frequency (event rate and event/patient/year). The time horizon was 12 months and the model only considered the medical direct costs. Results: After split the population (based on coverage pop at IMSS, very uncontrolled patients, diagnosed and treated), the cost model considered 40,439 DT1 patients. Without intervention, it was modelled 15,468 hypoglycemic events ($6.9 million dollars. Every treatment scenario was weighted according to literature review inputs). With intervention on base case scenario and best case (77.81% and 90.24% reduction on severe events) the frequency of severe events were 3,432 and 1,509, respectively (which it means a total costs that oscillate between $1.5 million and $675k dollars) ConClusions: The savings due to intervention (SAP) were described between $5.4 to 6.2 million of dollars. The analysis just account for those avoided acute events, we did not simulate those mid-term or long-term complications avoided neither indirect costs, items that could increase the effect size and costs savings due to SAP therapy on very uncontrolled DT1 patients.

was English language peer-reviewed PE studies describing scoring tools to evaluate methodological quality. Results: A total of 23 pharmacoeconomic scoring tools met the inclusion criteria. Findings revealed that although checklists and recommendations exist for evaluating the HC-PE literature, quantitative approaches are lacking. The checklists number of items ranged from 8-40 and focused on assessing risk of bias, study quality, and reporting standards. The checklists were useful in assessing the quality and methodology of PE studies, however, only one tool assigned points to each item. There were two tools that categorized each domain into qualitative grades, while the others did not assign scores. Conclusions: Appraising the quality of HC-PE literature has become increasingly important for decision makers and those conducting systematic reviews. There is a lack of validation and variability in the criteria which is not weighted. The performance of an effective assessment requires qualitative as well as quantitative aspects. Future research will include the development of such tool.

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