Background Much interest has not been placed on the role of chromosomal abnormalities in the pathogenesis and rising prevalence of infertility in recent times. This review was conducted to renew public interest on the chromosomal basis of infertility, testing, and management. Main text Meiotic and post-zygotic mitotic errors may cause infertility-predisposing chromosomal abnormalities, including Klinefelter syndrome, Jacob syndrome, Triple X syndrome, Turner syndrome, and Down syndrome. Chromosomal abnormalities such as deletion, translocation, duplication, inversion, and ring chromosome may also predispose to infertility. Notable features of male chromosomal infertility include spermatogenic failure, characterized by azoospermia, oligospermia, and gonadal dysgenesis, while females include premature ovarian insufficiency, amenorrhea, spontaneous abortion, and gonadal dysgenesis. The risk of these abnormalities is influenced by maternal age and environmental factors such as chemical exposure, smoking, and alcohol consumption. Most chromosomal abnormalities occur spontaneously and are not treatable. However, early prenatal screening and diagnostic tests can lessen the effects of the conditions. There is also a growing belief that certain diets and drugs capable of changing gene expressions can be formulated to neutralize the effects of chromosomal abnormalities. Conclusion Meiotic and mitotic errors during gametogenesis and fetal development, respectively, can cause chromosomal abnormalities, which predispose to infertility. Couples who are at increased risk, particularly those with a family history of infertility and women at an advanced age (≥ 35 years), should seek medical advice before getting pregnant.
A survey was conducted to determine the prevalence of HIV/AIDS related opportunistic infections from the patients attending the five major Hospitals in Kebbi State , which included Federal Medical Center (FMC), Birnin Kebbi, Sir Yahaya Memorial Hospital (SYMH), Birnin Kebbi, General Hospital, Argungu (GHA), General Hospital , Yauri (GHY) and General Hospital , Zuru (GHZ). The screening for the HIV/AID was done using the Genic II HIV-1/HIV -2 Test and the screening for opportunistic infections was done using thin and thick blood films, direct wet mount, formal ether concentration technique and modified Ziehl -Neelsen (ZN) technique. Microbial Pathogens were isolated through culture and identified through gram staining and biochemical tests. Out of the 1950 patients screened for HIV/AIDS infection, 606 (31.6%) were positive. Higher prevalence 195 (32.2%) was from FMC and the lowest from GHY 90 (15%). The result revealed that 374 (61.7%) of HIV/AIDS positive patients were also positive to one or more opportunistic infections. In this respect, higher prevalence of 32.3% was observed from FMC and the lowest was observed from SYMH with 13.9%. The result of the study also revealed the presence of malarial (Plasmodium) parasites with prevalence of (75.9%).The Federal Medical Centre (FMC) had the highest prevalence of 29.5%, SYMH, 21.7%, GHA, 17.2%, GHY, 16.1 and lastly GHZ with 15.4%. There is therefore the need for urgent positive control programme of HIV and HIV related opportunistic infections.
Background The literature shows that ABO blood groups and demographic characteristics influence susceptibility to type 2 diabetes mellitus (T2DM) and may be used to stem the rising incidence of the disease. However, these associations vary geographically, which necessitates the need to determine the association in every locality. This study determined the ABO blood groups and demographic characteristics of 486 type 2 diabetic patients with no family history in selected hospitals in Lagos, Nigeria. Results The results showed that age class 50–59 years (35.8%) was the most susceptible to T2DM, while age class 30–39 years (8.6%) was the least. Female diabetics accounted for 56.8%, while males constituted 43.2%. Diabetes was less prevalent among singles (9.5%), while married couples had the highest prevalence (55.6%). Primary school leavers were the least diabetic (9.9%), while secondary school leavers were the most diabetic (41.6%). Approximately 59.05% of the patients were overweight, while 5.35% were underweight. Blood group O positive was the most prevalent (38.5%; p < 0.05), followed by A positive (20.2%; p < 0.05), and the least was AB negative (4.5%). Severe conditions were less common among groups O positive and A positive (p < 0.05) compared to other blood groups. Thus, the relatively high prevalence of T2DM among blood groups O and A could be due to natural selection owing to their fitness. Conclusions ABO blood groups and demographic characteristics influenced the prevalence of T2DM in the city. Residents with blood groups O and A positive should pay special attention to T2DM.
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