Interferon was identified in the milk of mice injected with an interferon inducer. The kinetics of interferon appearance in serum and in milk were similar, but maximum concentrations in milk were 10 to 20 percent of those in serum. Interferon administered orally to neonatal mice was detected in their serums. Significantly more newborns survived an oral challenge with vesicular stomatitis virus when interferon had been induced in the lactating mothers.
The Indian River citrus-growing region is an area of Florida where many citrus trees are planted on sour orange rootstock. Many of these trees are currently experiencing rapid decline due to citrus tristeza virus (CTV). Three non-decline-inducing (NDI) isolates of CTV were evaluated to determine their effectiveness as cross protecting agents against decline-inducing strains of CTV. The three isolates were inoculated separately into grapefruit scions on sour orange rootstocks. Trees inoculated with NDI isolates of CTV as well as uninoculated trees were planted in an area with a high incidence of trees affected by CTV decline. Sixteen yr after planting, 86%, 90%, and 90% of trees inoculated with the three NDI isolates of CTV were unaffected by severe CTV as determined by negative reaction to the CTV MCA 13 monoclonal antibody. By the same criteria, only 33% of the unprotected trees were free of severe CTV.
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