Primary lymphomas of the central nervous system (PCNSL) are highly aggressive tumors affecting exclusively the CNS, meninges, and eyes. PCNSL must be separated from secondary spread of systemic lymphoma to the CNS (SCNSL), which may occur at diagnosis or relapse of systemic lymphomas. At present, there are no valid methods to distinguish PCNSL from SCNSL based on tumor biopsy because of similar histological presentation. However, SCNSL and PCNSL are different in terms of prognosis and adequate therapy protocols. MicroRNA expression profiles of CSF samples collected from SCNSL and PCNSL patients were compared using microRNA arrays. MiR-30c revealed the largest differential expression and was selected for validation by RT-PCR on 61 CSF samples from patients with PCNSL and 14 samples from SCNSL. MiR-30c was significantly increased in patients with SCNSL compared to PCNSL (p < 0.001). MiR-30c levels in CSF enabled the differentiation of patients with PCNSL from SCNSL with an area under the curve (AUC) of 0.86, with a sensitivity of 90.9% and a specificity of 85.5%. Our data suggest that miR-30c detected in the CSF can serve as biomarker for distinction between PCNSL and SCNSL. The validation in a larger cohort is needed. With respect to its function, miR-30c may facilitate lymphoma cells to engraft into CNS by interaction with CELSR3 gene that controls the function of ependymal cilia and, thus, affects the circulation of CSF.
The aim of the work was to achieve assumed gradation of hard coal particles distribution in epoxy matrix and thus gradation of properties. It was done by proper selection of compounds composition and conditions of the gradation formation. The graded composites were produced using centrifugal casting. Two types of epoxy resins as a matrix and two types of hard coal of various granulation as a filler were used. Samples in the form of bushings with radial carbon filler gradation were produced by changing filler type, its volumetric content and parameters of centrifugal casting. The first part of the paper presents results of graded materials structure investigations. The microscopic observations of the structure of composites prepared according to elaborated experimental program show that the composites are characterized by continuous change of the filler particles content in radial direction, so they can be classified as graded materials. Results also show that gradation of particles content and thus gradation of properties may be planned and foreseen when mechanisms of gradation formation are known.
The goal set for this paper was to investigate the relationship between gradation of filler particles content in the epoxy matrix and the gradation of electric properties. In order to characterize the electric properties, the surface resistivity was selected, because it determined the surface ability to electrostatic charging, important in expected applications. In particular, the influence of conditions of centrifugal casting technique and microstructure parameters on electric resistivity was searched. Experimental models were elaborated that juxtapose the dependence of surface resistivity on the volumetric content of the filler, as well as casting rotational velocity. Investigations results confirmed that achieved graded composites were characterized by the reduced ability of electrostatic charging on one side and good insulating properties on the other side. Measured surface resistivities of order 109–1011 Ω allow to classify them as surfaces with reduced susceptibility to static electricity accumulation. These composites may be applied in areas where antistatic properties of the surface, with preservation of insulating properties in the remaining volume of the composite, are beneficial.
The influence of the storage time on the useful properties (cohesion, adhesion, stickiness) of silicone pressure-sensitive tapes (Si-PSA) was investigated. Two types of silicone resins PSA 529 and PSA 590 (Momentive, USA) were used and crosslinked with bis (2,4-dichlorobenzoyl) peroxide (DClBPO). There was no significant effect of tapes long-term storage (7 years) on their properties. The tapes based on PSA 590 resin were more resistant to aging than PSA 529.
This article presents the technology of making an adhesive joint using two primers: Corrosion Inhibiting Primer BR127 (previously used, containing chromium compounds) and, as a potential substitute, Structural Adhesives Primer EW 5000 AS (which does not contain any compounds harmful to the environment). An adhesive film and a sol–gel primer were used to make the joint of two aluminum sheets, and various technologies were used for applying adhesion promoters. The mechanical properties of the prepared samples were tested using two test methods: wedge tests and shear strength tests. In both cases, the samples were aged in laboratory conditions in tap water, and in a climatic chamber (with increased temperature and humidity). The obtained results indicate that the best technology for preparing the joint using each primer is the technology that assumes heating the primer and hardening the adhesive film in one operation. The results of the strength tests indicate that the samples made using the EW 5000 AS primer have higher strength properties under all tested seasoning conditions compared to samples made using the BR 127 primer. It was also confirmed that the presence of moisture and/or water reduces the mechanical strength of the adhesive joints independently of the primer used. The results of the polymer coatings tests to protect the aluminum substrate against corrosion showed that the coatings are only effective for a certain period of time, and, as a result of the NSS test, after 480 h, all the samples were subject to corrosion.
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