The aim of the present review is to summarise the knowledge about newly isolated acetogenins (ACGs) in the last six years. It will also report the total syntheses that have allowed either the confirmation or the revision of some structures, together with the biological activities and mechanism of action of such interesting natural products. In fact, of the 417 isolated compounds reviewed, over 176 have been added during the period from 1998 to 2004.

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Organic chemistry Z 0200 Acetogenins from Annonaceae: Recent Progress in Isolation, Synthesis and Mechanisms of Action -[171 refs.]. -(BERMEJO, A.; FIGADERE, B.; ZAFRA-POLO, M.-C.; BARRACHINA, I.; ESTORNELL, E.; CORTES*, D.; Nat. Prod. Rep. 22 (2005) 2, 269-303; Dep. Farmacol.,

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Two novel metabolites of mixed biogenesis, polycerasoidin [1] and polycerasoidol [2], have been isolated from the stem bark of Polyalthia cerasoides. Their structures were established on the basis of nmr spectroscopic techniques, including 2D correlated nmr spectroscopy (COSY 45, HMQC, and HMBC).The genus Polyalthia includes more than 150 species of trees belonging to the family Annonaceae. It is considered one

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Seven different flavonoids from the aerial parts of Thymus webbianus were isolated. They were identified by UV spectra, TLC and HPLC-DAD as luteolin, api­genin, eryodictiol, naringenin, luteolin-7-O-glucoside, apigenin-7-O-glucoside and apigenin-6,8-di-C-glucoside. Other phenolics characterized by HPLC-DAD analysis were: protocatechuic, chlorogenic, syringic, p-coumaric and 3,5-dicaffeoylquinic acids.