When announcing his decision to withdraw the United States from the Paris Agreement, President Trump reminded the world that, "I was elected to represent the citizens of Pittsburgh, not Paris." In doing so, he repeated a tired trope: that Pittsburgh is a rusty urban relic-a manufacturing city of steel that has fallen on hard times, held back by unfair global competition and onerous environmental regulation. But such a nostalgic version of Pittsburgh, and of many other communities across the country, is a myth. If the president truly wants to represent the interests of Americans, he would learn from the real histories of these regions and promote economic and environmental progress through research, education, and innovation. Biographer James Parton, visiting Pittsburgh in its manufacturing heyday, described the smoky, sooty landscape as "hell with the lid taken off." By the early 1940s, after decades of leading the nation in steel production, the city was paying a heavy price for its economic success. Industry leaders, realizing that environmental catastrophe would be bad for business, partnered with local government in one of the country's first clean air initiatives. Environmental regulations did not drive the region's coal industry-long the engine of manufacturing-to collapse. That industry's fate is more intricately tied to the availability of low-cost natural gas, whose rise-including the shale gas boom-was buoyed by U.S. research efforts during the oil embargo of the 1970s. A lack of innovation and investment were the true linchpins of Pittsburgh's economic distress. Its aging and inefficient factories were unable to compete with foreign firms. The city lost nearly half of its population, unemployment peaked at 17% in 1983, and Pittsburgh became an economic shadow of its former self. The region clawed back from its economic breakdown by refocusing on technology innovation fueled by federally funded research at its major universities, especially Carnegie Mellon University and the University of Pittsburgh. Today, Pittsburgh is home to one of the most vibrant technology and health care markets in the country. It is teeming with startup companies and is an internationally recognized research leader in medicine, robotics, advanced manufacturing, big data, and autonomous systems. It is no accident that the top of the city's tallest building now advertises the University of Pittsburgh Medical Center-not U.S. Steel.
Stool specimens were collected from healthy neonates at Ga-Rankuwa Hospital in the winters of 1984 and 1986 and tested for the presence of rotavirus infection. Asymptomatic excretion was found to occur in 25% of the newborn babies analysed. Gel electrophoresis of the rotavirus RNA genome revealed that a genomically stable strain of rotavirus was endemic in the ward at the time intervals examined. Hybridisation analysis of the VP4 and VP7 rotavirus genes, which encode the outer capsid neutralization proteins of the virus, was conducted. These results showed the presence of a serotype 4 rotavirus strain with an M37-like VP4 gene allele, which remained conserved in the nursery over the time period examined. Partial nucleotide sequences were obtained for a variable region of the VP7 gene and for the hyperdivergent region of the VP4 gene from 8 of these viruses and showed that remarkable conservation of these regions in the genes of the viruses occurred over time.
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