2. Less than half of the embryos analyzed by PGD were normal in all three groups (41 AE 31%, 37 AE 38%, and 48 AE 31%, in MESA, TESA, and EJAC, respectively; Table 1) 3. There was no statistical difference in the rates of aneuploid, polyploid, haploid or euploid. 4. Complex Abnormalities were more common in the group of MESA than EJAC (48.3% versus 26.5%, p¼ .0005; Table 2). Conclusion: Despite the fact that MESA and TESE procedures are reserved for the most severe forms of male factor, rates of fertilization, embryo cleavage, pregnancy, and euploidy are similar to EJAC-derived embryos. The rate of aneuploidy in embryos derived from MESA and TESE is not higher than that found in EJAC-derived embryos. There is increased incidence of complex abnormal chromosomes in embryos derived from MESA. We therefore conclude that MESA and TESE followed by ICSI and PGD appears to be a plausible approach with results comparable to using ejaculated sperm.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.