In this paper, we study the dynamical properties of the exciton-polaron in the microtubule. The study was carried out using a unitary transformation and an approximate diagonalization technique. Analytically, the modeling of exciton-polaron dynamics in microtubules is presented. From this model, the ground state energy, mobility, and entropy of the exciton-polaron are derived as a function of microtubule's parameters. Numerical results show that, depending on the three vibrational modes (protofilament, helix, antihelix) in MTs, exciton-polaron energy is anisotropic and is more present on the protofilament than the helix and absent on the antihelix. Taking into account the variation of the protofilament vibrations by fixing the helix vibrations, exciton-polaron moves between the 1st and 2nd protofilaments. It is seen that the variation of the two vibrations induces mobility of the quasiparticle between the 1st and 15th protofilament. This result points out the importance of helix vibrations on the dynamics of quasiparticles. It is observed that the mobility of the exciton polaron and the entropy of the system are strongly influenced by the vibrations through the protofilament and helix. The effects of the one through the antihelix is negligible. The entropy of the system is similar to that of mobility. Confirming that the quasiparticles move in the protofilament faster than in the helix.
Microtubules as essential biopolymers implicated into electrical intracellular transport open a lot of questions about their intrinsic character of dynamic instability. Both experimental and theoretical investigations are used to understand their behavior in order to mimic and build powerful and smart biomaterials. So, in this paper, by analytical and computational approaches, we proposed an electrical analogue computer of microtubule’s protofilament drawing from the partial differential equation which describes microtubule’s motion. Using the computing elements, namely, operational amplifiers, capacitors, and resistors, we designed analytically the bioelectronic circuit of the microtubule’s protofilament. To validate our model, Runge–Kutta code was used to solve the partial differential equation of MT’s motion on software Matlab, and then, the results obtained are used as a controller to fit and validate numerical results obtained by running the bioelectronic circuit on software PSpice. It is shown that the analogue circuit displayed spontaneous electrical activity consistent with self-sustained electrical oscillations. We found out that two behaviors were exhibited by the voltage generated from the electrical analogue computer of MT’s protofilament; amplification and damping behaviors are modulated by the values of the resistor of the summing operational amplifier. From our study, it is shown that low values of the resistor promote damping behavior while high values of the resistor promote an amplification behavior. So microtubule’s protofilament exhibits different spontaneous regimes leading to different oscillatory modes. This study put forward the possibility to build microtubule’s protofilament as a biotransistor.
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