Background: Patient registries are one of the main Real-World Data (RWD) sources, which enable different healthcare stakeholders to analyze clinical practice, benchmark them and foster better care. Despite the growing need of RWD, the current use of patient registries in Portugal is not fully understood. This study aims to identify and characterize patient registries in Portugal to set a baseline for future developments in this domain.Methods: A systematic literature review was conducted and complemented with a literature search to identify registries in Portugal.Results: The study identified 108 unique registries in Portugal, 76 collecting data exclusively from Portuguese population. Most belong to medical societies or health authorities and are implemented in hospitals. Cardiology, Oncology, Endocrinology, and Rheumatology are the most studied therapeutic areas. Conclusion: Most registries have a national scope, but several are being used to complement international ones. This practice is common in Europe since guidelines to standardize data collection and foster practice benchmark exist. The majority are owned by medical societies or health authorities and the therapeutic areas seem aligned with health technology innovation. In the future a repository of information needs to be developed that embeds existing registries, to foster collaboration between stakeholders and promote better care.
English language up to 11th August 2017. We used a detailed list of search terms related to persistence and adherence of oral bisphosphonate treatment. In order to assess the quality of the studies we used the Newcastle e Ottawa quality assessment scale [NOS]. RESULTS: The search yielded 532 published studies, of which 89 were deemed relevant and were included in this review. The mean age of patients included within the studies ranged between 53 to 80.8 years, and the follow-up varied from 6 months to 14 years. The mean persistence of oral bisphosphonates for 6 months, 1 year and 2 years ranged from 38% to 79%, 12.6% to 77.6%, and 9.5% to 41.8%, respectively. The mean medication possession ratio (MPR), a measure of adherence, ranged from 58% to 92%. All the included studies scored the maximum applicable score of between 6 to 8 on the NOS. The determinants of adherence and persistence to oral bisphosphonates included geographic residence, marital status, tobacco use, educational status, income, race, hospitalisation and medication type and dosing frequency. CONCLUSIONS: The findings of this review suggest that patients' persistence with treatment was poor and dropped notably over the first two years. Overall, adherence was sub optimal. In order to maximize adherence and persistence to oral bisphosphonates it is important to consider their possible determinants including characteristics of the patients.
cost savings per patient ranged from V326 to V335 (France), V357 to V366 (Germany), V419 to V428 (Italy), and V590 to V599 (the Netherlands), depending on the dressing type used. Conclusions: Results of the economic analysis suggest that the introduction of the skin closure system and barbed suture for wound closure in knee arthroplasty can save costs to European hospitals due to reduced intra-and post-operative resource use.
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