The aim of the study was to compare the efficacy and safety of singledose prulifloxacin vs. single-dose pefloxacin in the treatment of patients with acute uncomplicated urinary tract infections. Two hundred and thirty-one female out-patients were considered microbiologically evaluable and randomly treated with 600 mg prulifloxacin (116 patients) or 800 mg pefloxacin (115 patients). The most commonly isolated uropathogen at baseline was Escherichia coli (71.4%), followed by Proteus mirabilis (10.8%) and Klebsiella pneumoniae (7.8%). Five-seven days posttreatment, the eradication rate was 97.4% and 92.2% in the prulifloxacin and pefloxacin group, respectively. The one-tailed 95% confidence interval analysis showed the equivalence of treatments. Four weeks from treatment no relapses, reinfections or superinfections were observed. The clinical success rates were 92.2% in the prulifloxacin and 84.3% pefloxacin groups. The safety profile was very good with both drugs. The results of the study make it possible to consider prulifloxacin a possible therapeutic option in patients with acute uncomplicated UTIs
The use of laparoscopically introduced mesh was adopted in order to correct all pelvic floor disorders, however today laparoscopic prostheses tend to be used increasingly for patients with prevailing apical prolapse: III and IV degree hysterocele and/or post-hysterectomy prolapse of the vaginal vault. The co-existence of other defects, for example cystocele and/or III degree rectocele, urethral hypermobility and/or urethrocele with associated urinary incontinence and above all the presence of these defects in an isolated form, usually indicates a vaginal surgical approach. Therefore the operation in which the application of laparoscopically introduced prostheses prevails is indirect promontory colpopexy (or sacrocolpopexy) and hysterosacropexy. At the beginning of the ‘90s, Dorsey [1] and Nezhat [2] were the first authors to describe laparoscopic sacral colpopexy, with dissection of the vagina anterior to the bladder and posterior to the rectum, in order to apply the mesh to the anterior and posterior wall of the vagina. The method then became widely used and was perfected, and it tended increasingly to be performed together with the laparotomic approach. Wattiez [3] even claims that the laparoscopic approach is better than the vaginal and/or laparotomic approach for the treatment and/or prevention, not only of apical genital prolapse, but of the whole range of pelvic floor disorders. Therefore, considering the growing importance of the laparoscopic prosthetic correction of apical defects, the authors, on the basis of a revision of the literature, describe the following aspects: rational of the technique, type of prosthetic materials used, controversies regarding the method of application of the mesh and whether or not hysterectomy is also to be performed.........
The new tension-free techniques for treatment of either stress urinary incontinence or pelvic organ prolapse are shown. They are divided as follows. Techniques for the anterior compartment: TVT (Tension-free Vaginal Tape), Retropubic TUS (Tension-free Urethral Suspension), TOT (Transobturator Tape), Prepubic TUS (Tension-free Urethral Suspension), TCR (Tension-Free Cystocele Repair), Retropubic TICT (Tension-free Incontinence Cystocele Treatment), Prepubic TICT (Tension-free Incontinence Cystocele Treatment); Techniques for the apical compartment: Indirect abdominal colposacropexy; Techniques for the postero- apical compartment: Posterior IVS; Techniques for the posterior compartment: Colpoperineoplasty with mesh. Both a correct diagnosis and an appropriate procedure are the right key to achieve a greater therapeutic success
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