Since its first release over a decade ago, the MetaboAnalyst web-based platform has become widely used for comprehensive metabolomics data analysis and interpretation. Here we introduce MetaboAnalyst version 5.0, aiming to narrow the gap from raw data to functional insights for global metabolomics based on high-resolution mass spectrometry (HRMS). Three modules have been developed to help achieve this goal, including: (i) a LC–MS Spectra Processing module which offers an easy-to-use pipeline that can perform automated parameter optimization and resumable analysis to significantly lower the barriers to LC-MS1 spectra processing; (ii) a Functional Analysis module which expands the previous MS Peaks to Pathways module to allow users to intuitively select any peak groups of interest and evaluate their enrichment of potential functions as defined by metabolic pathways and metabolite sets; (iii) a Functional Meta-Analysis module to combine multiple global metabolomics datasets obtained under complementary conditions or from similar studies to arrive at comprehensive functional insights. There are many other new functions including weighted joint-pathway analysis, data-driven network analysis, batch effect correction, merging technical replicates, improved compound name matching, etc. The web interface, graphics and underlying codebase have also been refactored to improve performance and user experience. At the end of an analysis session, users can now easily switch to other compatible modules for a more streamlined data analysis. MetaboAnalyst 5.0 is freely available at https://www.metaboanalyst.ca.

The properties of the low-lying levels of '"Te were investigated by the Coulomb excitation process which was effected by bombarding a thick natural tellurium target with 9,5and 10.5-MeV 0. particles and a thick target of isotopically enriched '"Te (95%%uo) with 45-MeV ' 0 ions. Levels at 443.58, 463.39, 671.42, and 729.30 MeV were Coulomb excited and the reduced upward transition probabilities 8(E2t') (e'b) extracted from the. data were: 0.186 + 0.005, 0.158 + 0.005, 0.130 + 0.004, and 0.0059~0.0008. Angular distribution measurements were performed with 42-MeV ' 0 ions. The following results were obtained for the y rays deexciting the 443.58-(3/2') keV level: 8(408. 10)

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The eigenstates of an electron in the chiral two-dimensional electron gas (C2DEG) formed in an AB-stacked bilayer or an ABC-stacked trilayer graphene is a spinor with 4 or 6 components respectively. These components give the amplitude of the wave function on the 4 or 6 carbon sites in the unit cell of the lattice. In the tight-binding approximation, the eigenenergies are thus found by diagonalizing a 4 × 4 or a 6 × 6 matrix. In the continuum approximation where the electron wave vector k << 1/a0, with a0 the lattice constant of the graphene sheets, a common approximation is the two-band model 1 (2BM) where the eigenstates for the bilayer and trilayer systems are described by a two-component spinor that gives the amplitude of the wave function on the two sites with low-energy |E| << γ1 where γ1 is the hopping energy between sites that are directly above one another in adjacent layers. The 2BM has been used extensively to study the phase diagram of the C2DEG in a magnetic field as well as its transport and optical properties. In this paper, we use a numerical approach to compute the eigenstates and Landau level energies of the full tight-binding model in the continuum approximation and compare them with the prediction of the 2BM when the magnetic field or an electrical bias between the outermost layers is varied. Our numerical analysis shows that the 2BM is a good approximation for bilayer graphene in a wide range of magnetic field and bias but mostly for Landau level M = 0. The applicability of the 2BM in trilayer graphene, even for level M = 0, is much more restricted. In this case, the 2BM fails to reproduce some of the level crossings that occur between the sub-levels of M = 0.

Directional correlation measurements have been performed with two Ge(Li) counters on several γ rays in coincidence with the 121.78 and 334.31 keV γ transitions which de-excite the first 2+ levels in 152Sm and 152Gd, respectively. A total of 20 γ−γ directional correlations, 13 in the 152Sm nucleus and 7 in the 152Gd nucleus, was measured simultaneously. Several of the γ−γ directional correlations involved gamma transitions of weak intensity, for example the (688.66−121.78), (1457.4−121.78), and (1528.16−121.78) keV cascades in 152Sm and the (586.29−334.31) and (1089.73−334.31) keV cascades in 152Gd. Among the various results which could be extracted from these measurements, the most interesting appears to be the determination of a nearly pure E2 character for the 688.66, 964.01, 1112.04, and 867.33 keV gamma transitions. The first two γ rays de-excite the 2+ β- and γ-vibrational levels to the 2+ ground-state rotational level at 121.78 keV in 152Sm, whereas the last two γ rays de-excite the3+ γ-vibrational level to the 2+ and 4+ (at 366.44 keV) ground-state rotational levels in 152Sm.

The y rays emitted in the decay of the '52Eum,E isomeric pair have been studied with the use of highefficiency, high-resolution, solid-state detectors. These measurements together with Ge(Li)-Ge(Li) coincidence experiments revealed the existence of several new gamma transitions never previously reported. In all, 93 and 30 y rays were observed in the decay of 15'EuE and '52Eum, respectively. Calculations of the (3-and y-band mixing into the ground-state rotational band and into each other were carried out. These calculations showed that this mixing is insufficient in explaining the B(E2) ratios from the members of both the (3 and y band. In addition, the very likely existence of a K" = 2-band in 15'Sm, with levels at 1649.90 (2-) and 1757.0 keV (3-), has been unveiled in these measurements. Furthermore, the existence of a new K n = 0-octupole rotational band (levels at 1680.58 (I-) and 1730.3 (3-)) built on the B-vibrational band and the presence of a collective K n = 2 + vibrational state at 1769.1 keV, which most probably can be described as a coupled (By) two phonon state, are also proposed. Moreover, a new level at 1292.75 keV has been established through coincidence experiments in 15'Sm. This level may be considered either as the 2 + member of a second B-vibrational band or, more likely, can be described as a truly spherical state in light of recent experiments involving (t,p) and (p,t) transfer reactions to levels of 15'Sm. Finally, a qualitative analysis of the level structure of 15'Gd, as well as 150Sm, seems to show that these two nuclei display a more rotational nature than a spherical (or vibrational) one as previously suggested. Les rayons y Cmis lors de la dCsintCgration de la paire d'isom&res 15'Eum p g ont CtC CtudiCs en utilisant des detecteurs solides de grande efficacitk et haute rCsolution. Ces mesures et des expkriences de coincidence Ge(Li)-Ge(Li) ont rCvClC I'existence de plusieurs transitions gamma que personne n'avait encore signalkes. En tout, on a observC 93 transitions y dans la desintkgration de 15'Eug, et 30 pour 15'Eum. On a effectue des calculs sur le mClange des bandes (3 et y, I'une avec I'autre et avec la bande de rotation du niveau fondamental. Ces calculs montrent que ce mClange ne suffit pas a expliquer les rapports B(E2) observCs pour les membres des bandes (3 et y. Ces mesures ont de plus dCvoilC I'existence trCs probable d'une bande K" = 2-dans 15'Sm, avec des niveaux a 1649.90 (2-) et 1757.0 (3-) keV. On propose aussi I'existence d'une nouvelle bande octupolaire de rotation (niveaux ? i 1680.58 (1 -) et 1730.3 (3-)), batie sur la bande de vibration, ainsi que la presence d'un Ctat collectif de vibration K" = 2 + a 1769.1 keV, Ctat qui peut tres probablement Ctre dCcrit comme un Ctat couplC (By) a deux phonons. E n outre, les mesures de coincidences pour l5'Srn Ctablissent I'existence d'un nouveau niveau a 1292.75 keV. Ce niveau pourrait ou bien Ctre considCrC comme un membre 2+ d'une seconde bande de vibration (3 ou bien, plus vraisemblablement, Ctre dCcrit comme un Ctat vr...

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