1In unanaesthetized pigeons, kept at room temperature (20-23 C) the effects on cloacal temperature were examined of catecholamines, phenoxybenzamine and propranolol, injected into the cerebral ventricles. 2 Noradrenaline, adrenaline, dopamine and isoprenaline caused a fall in cloacal temperature. 3 Phenoxybenzamine produced a long-lasting small rise in cloacal temperature. This rise is attributed to removal of the hypothermic effect of noradrenaline released continuously from adrenergic neurones ending in the anterior hypothalamus. Propranolol produced a slight fall in cloacal temperature. 4 The hypothermic effects of noradrenaline, adrenaline and dopamine were prevented by phenoxybenzamine but not by propranolol. They are therefore attributed to activation of ct-adrenoceptors.
5The hypothermic effect of isoprenaline was not prevented by either phenoxybenzamine or propranolol. The effect can therefore not be attributed to activation of either a or ,B-adrenoceptors. Propranolol actually accentuated the isoprenaline-induced hypothermia.
Abstract-The present study demonstrates the optimum conditions required for sur vival of the adult Setaria cervi in-vitro and the effect of some drugs on these worms.
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