Background: Burn despite being easily preventable is a critical health problem worldwide. With effective managements there is decline in burn cases in developed countries but trend is still rising in developing countries like India. This study was conducted to know the socio-demographic profile and pattern of burn injury in patients admitted in burn unit of tertiary care hospital.Methods: A hospital based cross sectional study was conducted for a period of six months using semi-structured questionnaire for data collection. The patient or accompanying person was interviewed after taking consent. Clinical assessment was done to find% of total body surface area (TBSA) involved and most severely affected body part.Results: A total of 123 patients were admitted in burn unit. Female (72.3%) predominance was found with most common age group being 21-40 years. Majority was Hindus (72.4%), residing in rural area (79.7%) and married (60.2%). Accidental burn was in 92.7%, mostly occurring at home (91%). Flame burn was common in female and electric burn in male. Burn injury mostly involved up to 30% of TBSA (44.7%) with upper limb (39%) most severely injured. Only 35% were admitted on the same day of injury. Infection (57.7%) and amputation (7.3%) were two common complications. There were 12 (9.8%) deaths during the study period.Conclusions: Most vulnerable were female with flame burn due to unsafe cooking practices. Infection was the most common complication. Death was more in those who delayed admission in hospitals.
Jatropha curcas has been widely studied at the molecular level due to its potential as an alternative source of fuel. Many of the reports till date on this plant have focussed mainly on genes contributing to the accumulation of oil in its seeds. A suppression subtractive hybridization strategy was employed to identify genes which are differentially expressed in the mid maturation stage of J. curcas seeds. Random expressed sequence tag sequencing of the cDNA subtraction library resulted in 385 contigs and 1,428 singletons, with 591 expressed sequence tags mapping for enzymes having catalytic roles in various metabolic pathways. Differences in transcript levels in early and mid-to-late maturation stages of seeds were also investigated using sequence information obtained from the cDNA subtraction library. Seven out of 12 transcripts having putative roles in central carbon metabolism were up regulated in early seed maturation stage while lipid metabolism related transcripts were detected at higher levels in the later stage of seed maturation. Interestingly, 4 of the transcripts revealed putative alternative splice variants that were specifically present or up regulated in the early or late maturation stage of the seeds. Transcript expression patterns from the current study using maturing seeds of J. curcas reveal a subtle balancing of oil accumulation and utilization, which may be influenced by their energy requirements.
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