The effect of intravertebral infusion of propranolol (0.01 mg per kilogram of body weight) was compared to intravenous infusion of identical doses of propranolol so that any specific action of the drug on a possible vasomotor center in the brain stem may be assessed. Significant reductions (-25%) in CBF and CPP followed both intravertebral and intravenous infusion of propranolol. Cerebral metabolic rate for oxygen (CMRO 2 ) decreased significantly ( -18%) and cerebrovascular resistance (CVR) increased significantly ( + 19%) after intravertebral infusion of propranolol while less significant changes ensued following intravenous infusion of propranolol. Cerebral autoregulatory vasoconstriction during increases in CPP was significantly enhanced following both intravertebral and intravenous propranolol. Cerebral autoregulatory vasodilatation during decrease in CPP was not influenced by propranolol. Cerebral vasodilatory responsiveness to CO 2 inhalation was significantly inhibited following intravertebral propranolol while no significant change resulted from intravenous propranolol. Cerebral vasoconstrictive responsiveness to hyperventilation was not influenced by propranolol.These results indicate that the CBF and CMRO 2 are reduced by a pharmacological beta adrenergic blockade with propranolol hydrochloride.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.