A new, mild, one-pot method for the synthesis of cyclobutabenzenes by the zirconium-promoted cross-coupling reaction of aryllithium compounds and alkenyl bromides is reported. Formation of an arynezirconocene complex and its regioselective coupling with an alkenyl bromide are the key steps of the process. This method allows the regio- and diastereoselective synthesis of functionalized cyclobutabenzene derivatives from simple and easily available starting materials.
Carbon monoxide (CO) intoxication continues to be one of the most common causes of morbidity due to poisoning. The toxicity is caused by a combination of tissue hypoxia and direct CO‐mediated damage at the cellular level (1). Neurologic consequences of CO poisoning have been most often reported. Loss of consciousness, intermittent convulsions and respiratory failure may appear when carboxyhaemoglobin (COHb) concentrations of 60–80% are reached (2). However, it is important to recognize that COHb levels do not correlate with the severity of symptoms in a substantial number of cases (1). Pathological findings include necrosis and degeneration of the globus pallidus (3) and destructive lesions of the cerebral white matter (4). Computer tomography (CT) commonly shows bilateral low‐density areas in the globus pallidus (2–6) and low‐density lesions in the white matter (4). Magnetic resonance imaging (MRI) is more sensitive in detecting these lesions which appear as hyperintense signals in basal ganglia on T2 weighted images (4, 5). Neuropathological and radiological findings are well correlated (3).
Carbon monoxide (CO) intoxication continues to be one of the most common causes of morbidity due to poisoning. The toxicity is caused by a combination of tissue hypoxia and direct CO‐mediated damage at the cellular level (1). Neurologic consequences of CO poisoning have been most often reported. Loss of consciousness, intermittent convulsions and respiratory failure may appear when carboxyhaemoglobin (COHb) concentrations of 60–80% are reached (2). However, it is important to recognize that COHb levels do not correlate with the severity of symptoms in a substantial number of cases (1). Pathological findings include necrosis and degeneration of the globus pallidus (3) and destructive lesions of the cerebral white matter (4). Computer tomography (CT) commonly shows bilateral low‐density areas in the globus pallidus (2–6) and low‐density lesions in the white matter (4). Magnetic resonance imaging (MRI) is more sensitive in detecting these lesions which appear as hyperintense signals in basal ganglia on T2 weighted images (4, 5). Neuropathological and radiological findings are well correlated (3).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.