Gold, sulphur and mercurial formulations in Indian alchemy are consumed in conjunction with suitable adjuvant for the better result of their synergistic action, reduced toxicity and consequently boosting their bioavailability via the body's cells due to their nano size resulting in improved effectiveness. Poorna chandrodaya chendooram is a well-known mercurial mixture containing gold and sulphur that has traditionally been used to treat a variety of diseases including tuberculosis, jaundice, fever, rat-bite, malignant ulcer, sprue, and male sterility. Fel bovinum purifactum ( Gorochanai ) is an expectorant. It is used to treat fever, nausea, dyspnea, general weakness, headache, and other symptoms in children. Gorochanai pill relieves asthma, hiccups, cough, and Hemiplegia. It acts as a bronchodilator. The second wave mutant virus has better transmission potential and a shorter incubation period than the first wave. Some diabetic patients treated for SARS-CoV-2 with high dose corticosteroids had a decrease in angioinvasive maxillofacial fungal infections (Mucormycosis). Without using synthetic steroids and with optimum oxygen support, this case report emphasises the therapeutic success of administering Poorna chandirodayam and Gorojanai mathirai together with herbal and herbomineral Siddha formulations as a supplementary when required in the early inflammatory phase of COVID-19 infection and hypoxic situation. 5 patients with the laboratory-confirmed diagnosis of coronavirus (SARS- CoV2) infection admitted in the approved Siddha Covid hospital have been involved in the study. When the drug is properly prepared and given in a safe dosage during the duration of treatment there will not be any side effects. Metal-based medications Poorna chandirodayam and Gorojanai mathirai been demonstrated through these case series to be safe and useful in COVID19.