Abstract-Hepatocyte growth factor (HGF) promotes the survival and migration of immature neurons, but its role in the mature brain has remained elusive. In the hippocampus of juvenile rats, we found that the HGF receptor c-Met was expressed in neurons. Furthermore, it was highly Tyrphosphorylated, more so than in the liver under normal conditions, suggesting that the receptor is activated and that HGF may act continuously in the intact brain. Exogenously applied HGF enhanced synaptic long-term potentiation (LTP) in the CA1 region of hippocampus, but did not affect long-term depression. We further found that HGF augmented N-methyl-D-aspartate receptor-mediated currents in both slices and dissociated neurons. This augmentation is likely to underlie the enhancement of LTP. Considering that the expression of both HGF and c-Met are known to be induced by ischemic stimuli, this modulation would provide a novel understanding of a neuronal regulatory systems shared with pathogenic ischemic states.
Correlations between latencies of P300 components in evoked potentials and reaction times were investigated in two normal subjects. The subjects were required to perform choice reaction tasks, responding to particular tones among three tones with different frequencies. EEGs were recorded at the Pz region monopolarly. Latencies of P300 for individual EEG responses were measured employing an adaptive correlating filter. Cross‐correlation coefficients between the second templates employed to identify P300s and individual responses for the subjects ranged from 0.623 to 0.997, with the mean value being 0.931. The correlation coefficient between latencies of P300 and reaction times for the subjects was 0.659. Thus, the adaptive correlating filter was proved to be useful in psychophysiological studies.
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