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Recent evidence from our laboratory and others have suggested that the mechanism for a decrease in resting blood pressure after an acute bout of exercise is a centrally mediated decrease in total peripheral resistance. This study examined the effect of the central serotonergic system on post exercise hypotension (PEH) in 11 borderline hypertensive individuals (nine male, two female) aged 24.5 ؎ 5.1 years. Each subject completed two, 30-min cycling bouts at 70% of V O 2 Peak while under placebo or a selective serotonin re-uptake inhibitor (SSRI) treatment. Blood pressure was recorded directly from the radial artery, and treatments were randomised, double blinded and separated by at least 14 days. Baseline blood pressure was 145/72 mm Hg for systolic (SBP) and diastolic (DBP) respectively. Peripheral measures of serotonin (5-HT) were lower under SSRI treatment, whereas the major 5-HT metabolite, 5-hydroxyindoleacetic acid, was not significantly changed,

Creatine treatment in muscle disorders: a meta-analysis of randomised controlled trials Creatine is a naturally occurring amino acid derivative that is obtained by endogenous synthesis and dietary intake. Creatine phosphate has a high phosphoryl group transfer potential and serves as an ATP buffer during muscle contraction. Creatine supplementation increases muscle strength in healthy persons. OBJECTIVESThe aim of our review was to evaluate the efficacy and safety of creatine supplementation in muscle diseases. METHODSWe evaluated randomised controlled trials of creatine supplementation in patients with hereditary muscle diseases. The primary outcome measure was the change in muscle strength determined by quantitative muscle testing. Secondary outcomes were the change in muscle strength measured by manual muscle testing, changes in energy parameters assessed by 31-phosphorous spectroscopy, the change in (a surrogate for) muscle mass and adverse events. Figure 1 Meta-analysis of change in maximum voluntary contraction (MVC) in muscular dystrophies. Weighted mean differences in MVC after creatine supplementation compared with placebo. Reproduced from Kley et al with permission from Wiley. Cochrane neurological network corner 366