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The five years old boy with recurrent respiratory tract infections was under observation of infectiologist due to high levels of human herpes virus type 6 (HHV-6), found in patient’s blood and saliva during a few years. The patient got the medicines against the HHV-6, without any effect. We investigated the patient’s and his mom’s nails and found the HHV-6 type B, so it was inherited chromosomal integrated HHV-6. Thus, to avoid the unnecessary treatment, in case of repeated high level of HHV-6, we need to exclude chromosomal integrated HHV-6.

Вирусы герпеса человека 6 и 7 типа (ВГЧ-6, ВГЧ-7) повсеместно распространенные возбудители, вызывающие ряд острых болезней у детей. В отличие от хорошо изученного ВГЧ-6, в мире существуют лишь единичные исследования, посвященные ВГЧ-7. Целью нашей работы было сравнить клинические и лабораторные проявления ВГЧ-7-и ВГЧ-6-инфекции. Материалы и методы. Обследовано 684 пациента от 10 дней до 6 лет жизни, поступивших в стационар с лихорадкой, методом ПЦР плазмы крови. Результаты. Только у 4% пациентов был выявлен ВГЧ-7, у 22%-ВГЧ-6 (p<0,01). Средний возраст пациентов с ВГЧ-7 был выше (20,6±3,1), чем у пациентов с ВГЧ-6 (11,6±0,6) (p<0,01). ВГЧ-7 чаще (50%), чем ВГЧ-6 (5%) сопровождался лихорадкой без сыпи (p<0,01), реже сопровождался лимфоцитопенией (p<0,01). Выводы. Полученные данные могут свидетельствовать о большей частоте бессимптомной формы первичной инфекции и более легком течении ВГЧ-7-инфекции по сравнению с ВГЧ-6-инфекцией. Êëþ÷åâûå ñëîâà Вирус герпеса человека 7 типа, вирус герпеса человека 6 типа, ВГЧ-6, ВГЧ-7, внезапная экзантема, лихорадка без сыпи, фебрильные судороги Summary Human herpes viruses 6 and 7 (HHV-6, HHV-7) are widespread pathogens causing acute febrile illnesses in children. In contrast with HHV-6, the characteristics of HHV-7 are not well studied yet. Th e aim of the study was to compare clinical and laboratory features of HHV-7 and HHV-6 infections. Methods. PCR of plasma in 684 children with fever from 10 days to 6 years old was investigated. Results. Only 4% of patients had HHV-7 compared to 22% with HHV-6 (p<0,01). Th e mean age of patients with HHV-7 (20,6±3,1) was signifi cantly higher then the age of HHV-6 patients (11,6±0,6) (p<0,01). Th e children with HHV-7 more oft en had fever without the rash (50%) (p<0,01), while only 5% patients with HHV-6 had this form of infection. Also lymphocytopenia was less often in patients with HHV-7 (p<0,01). Discussion. It can be suggested that HHV-7 infection is oft en asymptomatic and has easier course of disease then HHV-6.

Background. There are no data on HHV-7 seroprevalence in Russia. Previously we detected HHV-7 DNA in plasma of 8-10% children with exanthem subitum and fever without rash. Aim. To perform the comparative study of the seroprevalence of HHV-7 and HHV-6 in children in Russia. Materials and methods. The pilot study included 116 children, aged from 10 days to 10 years. Serum samples were tested for IgG to HHV-7 and HHV-6 by indirect immunofluorescent assays and ELISA correspondingly. Results. The prevalence rate antibodies to HHV-7 was three times lower than for antibodies to HHV-6. There were only 18% of patients seropositive to HHV-7, whereas 50% of cases appeared to be seropositive to HHV-6. In infants younger 6 months the frequency of HHV-7 seropositivity amounted to 14.8%, which possibly was due to maternal antibodies. In babies aged from 7 months to 4 years, the HHV-7 seroprevalence was about 7-13%. In children older than 4 years the rate of seropositivity raised to 31%. Conclusion. We can conclude that in life the contact with HHV-7 occurs later than to HHV-6, predominantly after the age of four years. In children under 10 years, the seroprevalence to HHV-7 is lower than to HHV-6. The sample size of our study is too small to extrapolate on Russian population and other seroprevalence studies are needed.

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