Summary:Three cases of multidrug-resistant Salmonella typhi infection presenting as spontaneous splenic rupture are presented. One patient died and two recovered completely. This is a previously unreported presentation of typhoid fever.
This study was undertaken to assess the efficacy of Norjloxacin, and oral quinolone, in Norfloxacin is an oral fluro-quinolone carboxylic acid compound with a wide bacterial spectrum against both gram positive and gram negative organisms.•-• Antibiotic resistance to Norfloxacin is uncommon because of its inhibitory action on bacterial DNA gyrase, M an enzyme essential for bacterial for DNA replication.Salmonella typbi infections are important problems in clinical medicine, and the introduction of new antimicrobials bas resulted in the emergence of resistance to the antibiotics, which is often mediated by R-plasmids. '•' The resistance to chlorampbenicol is reported in the U.S.10 and in India. It has been reported at an alarming rate of 300Jo.
11Published data are insufficient to assess the efficacy of Norfloxacin for therapy of typhoid fever and typhoid carriers.12 Our study discusses the role of Norfloxacin in multiple drug resistant salmonella typhi infections in 45 patients.
MethodsThis study was conducted in the Department of Medicine, SMHS Hospitals, Srinagar. Forty-five patients clinically diagnosed with enteric fever (prolonged fever, GI symptoms, prostration, and spleenomegaly), and confirmed by bacteriological/serological tests, were enrolled in the study. All bad been treated for enteric fever with cbloramphenical/contrimaxazol with furoxone in adequate doses for a period of at least eight days before reporting to this hospital. None of these patients bad shown a clinical response and were persistently febrile and toxic. Culture negative patients were not included in the study.
Mlcro biologic. al methodsFor blood culture with all sterile precautions, IO ml of a patient's blood was taken, S ml each introduced in Bile Broth Media and Glucose Broth Media. It was incubated at 37 °C, making daily subcultures onto MacConkey's and blood Agar Media. Non-lactose fermenting colonies were studied in detail for morphology, motility, biochemical reactions, and seroaggulutination with specific antisera. Antibiotic sen-JIMA: Volume 23, 1991
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