An investigation of the indole alkaloids of Haplophyton
crooksii has resulted in the identification
of two new alkaloids10-methoxy-N1-methylpericyclivine
(1) and 16-decarbomethoxyvinervinine (2)and 13 known alkaloidscrooksiine, yohimbine,
β-yohimbine, crooksidine, decarbomethoxytetrahydrosecodine, akuammicine, tubotaiwine, lanceomigine,
lanceomigine N-oxide,
haplophytine, cimicine, cimicidine, and akuammidinas major alkaloids
of this shrub. All of
the isolated alkaloids showed an inhibition of acetylcholinesterase
activity in vitro.
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