To effectively monitor and control the severe mining-induced rockburst in deep fault area, the fault activation law and the mechanical essence of rockburst induced by crossing fault mining were studied through theoretical analysis, microseismic monitoring, field investigation, and other methods; numerical simulation was employed to verify the obtained fault activation law and the mechanical nature. First, the distribution of microseismic sources at different mining locations and the fault activation degree were analyzed. According to the microseismic frequency and the characteristics of the energy stage, the fault activation degree was divided into three stages: fault stress transfer, fault pillar stress behavior, and fault structure activation. It was determined that the impact disaster risk was the strongest in the stage of the fault pillar stress behavior. Based on the periodic appearance law of microseisms in fault area, three types of conceptual models of fault-type rockburst were proposed, and the rockburst carrier system model of “roof-coal seam-floor” in the fault area was established. The mechanical essence of fault-type rockburst was obtained as follows: under the action of fault structure, the static load of the fault coal pillar was increased and superimposed with the active dynamic load of the fault, leading to high-strength impact disaster. Finally, the prevention and treatment concepts of fault-type rockburst were proposed. The monitoring and prevention measures of fault-type rockburst were taken from two aspects: the monitoring and characterization of fault rockburst and weakening control of the high static load of the fault coal pillar and dynamic load of fault activation. The proposed concepts and technical measures have been verified in the working face 14310 of Dongtan Coal Mine with sound results. The research results have a guiding significance for the prevention and control of rockburst in a similar mining face under crossing fault mining.