MECHANISMS IN HEMATOLOGYMECHANISMS IN HEMATOLOGY is a book with an accompanying interactive CD-ROM designed to assemble basic concepts that underlie clinical understanding and progress. It is presented as a concise text with a series of diagrams that distill diffuse information into a compact form. The interactive CD, in particular, brings many of the processes "to life" as details of the more complex pathways are conveyed in clear visual images. The text begins with the basic molecular biology that underlies hematological and oncological physiology/pathology-cell signaling, adhesion molecules, and apoptosis. This is followed by sections, among others, on hematopoiesis, iron, B 12 , and folate metabolism, neutrophil function, immunoproteins, chemotherapy, and coagulation. With the permission of the authors and publisher, STEM CELLS has reproduced the section on apoptosis, which we think our readers will enjoy.
MECHANISMS IN HEMATOLOGYMECHANISMS IN HEMATOLOGY is a book with an accompanying interactive CD-ROM designed to assemble basic concepts that underlie clinical understanding and progress. It is presented as a concise text with a series of diagrams that distill diffuse information into a compact form. The interactive CD, in particular, brings many of the processes "to life" as details of the more complex pathways are conveyed in clear visual images. The text begins with the basic molecular biology that underlies hematological and oncological physiology/pathology--cell signaling, adhesion molecules and apoptosis. This is followed by sections, among others, on hematopoiesis, iron, B 12 and folate metabolism, neutrophil function, immunoproteins, chemotherapy and coagulation. With the permission of the authors and publisher, STEM CELLS has reproduced the section on lymphocytes, which we think our readers will enjoy.STEM CELLS 1999;17:180-188 "To be or not to be-that is the question." Hamlet, Act III Scene I.On the peripheral blood smear, the lymphocyte appears the least interesting of all the leukocytes-the monotonous sameness of appearance gives no clue to its complex history, its present function or its future; nor can we differentiate between the T cells responsible for cellular immunity and the B cells that provide humoral immunity. In the peripheral blood about 70% of circulating lymphocytes are T cells, 15% are B cells and 15% are natural killer (NK) cells.The lymphoid immune system consists primarily of quiescent T and B cells-each potentially responsive to a unique antigen. Following recognition of foreign antigen, the immune attack is mediated by expanded clones of antigen-specific T and B lymphocytes. NK cells exist as preactivated cytotoxic cells: their effector response is rapid, without the need for prior activation.
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