Apathy is not only associated with cognitive impairment, but also with impaired daily functioning, caregiver burden and distress, medication noncompliance, and increased mortality. Differentiating apathy and depression, understanding their unique effects, and appropriately identifying apathy symptoms in patients have robust implications for the development of neuropsychological models of these effects in PD as well as practical implications in guiding improvements to patient care and enhancing quality of life in patients and caregivers.

This study investigated the relationship between dysphoria and two distinct kinds of relationship-related loss: relationship loss and loss of self in a relationship. Three models were evaluated. The first model predicts that only intimate relationship loss will be associated with increased dysphoria. The second model predicts that only loss of self will be associated with increased dysphoria. The third model predicts that an interaction between relationship loss and self-loss will be associated with greater dysphoria. Undergraduates ( N= 257) completed measures of relationship loss, self-loss, and two dysphoria measures. For both men and women, the study and an independent replication ( N= 172) clearly supported the self-loss model and not the alternatives.

This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The University of Rochester School of Medicine and Dentistry designates this educational activity for a maximum of 3.25 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity. The Symposium consists of three keynote speakers and four platform presentations by the following individuals, with allotted time for questions and answers after each presenter.

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