Isolated cold stress tests were used to evaluate the thermoregulatory capacity in the feet of 19 patients with interstitial cystitis (IC) and of 11 healthy volunteer control subjects. Mean pedal skin temperature fell more rapidly in the IC group as compared with controls; significant differences were found at 10-min (P = 0.002) and 20-min (P = 0.0008) cooling. Mean skin temperature remained lower in the IC group throughout the study. Sixteen feet (42%) in the IC group and five (22%) of the control feet failed to return to within 2 degrees C of baseline temperature during the 20-min recovery period. These findings may reflect abnormal vasomotor control in the IC group and, if so, may be indicative of increased spinal sympathetic activity in interstitial cystitis.
There are indications that the process of clearance of inhaled insoluble plutonium compounds from the lung may be represented by a model consisting of three exponential phases. A survey of published data on "in viuo" and bioassay measurements made after 239Pu0, inhalation by men and large animals has been carried out, and the half-times of the three exponential phases determined as approx 1 day, 30 days and 500 days.
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