Twenty two c h i l d r e n (age range :3-14 years, Sex:m:f: :12:lO) adm i t t e d t o Kings County H o s p i t a l o f Brooklyn w i t h s t a t u s asthmaticus were s t u d i e d t o determine t h e i r plasma ADH l e v e l s i n r e l a t i o n t o the s e v e r i t y o f the s t a t u s asthmaticus. Plasma ADH l e v e l s were measured b y RIA a t t h e time o f admission and again a t 1-2 weeks f o l l o w i n g recovery from s t a t u s . The r e s u l t s are shown i n t h e table.We conclude from t h e study t h a t 1. AOH r esponse increases w i t h s e v e r i t y o f s t a t u s asthmaticus 2. With h i g h sp. g r . o f u r i n e d u r i n g s t a t u s , i n add i t i o n t o dehydration increased ADH s e c r e t i o n should be k e p t i n mind and 3. I n a d d i t i o n t o o t h e r known f a c t o r s , increased ADH may p l a y a r o l e i n pulmonary edema w i t h s t a t u s asthmaticus.GROUP I GROUP I I n=14 n =8 W e s t u d i e d t h e v e n t i l a t o r y response t o hypoxia i n 7 newborn k i t t e n s (n=12), 2 t o 28 days o l d , K i t t e n s were s u r g i c a l l y instrumented t o record diaphragmatic EMG (EMGD~), eye movements (EOG), e l e c t r o c o r t i c a l a c t i v i t y (ECoG), and neck EMG, Ventilat i o n (OE) was measured with a mask and a flow-through system. K i t t e n s i n h a l e d 21% 02 f o r a c o n t r o l period of a t l e a s t 2 min, 10% 02 f o r 10 min, and 21% 02 f o r 2 min again. Measurements were made i n q u i e t s l e e p . With a decrease i n Fi02 t o lo%, t h e r e was an immediate i n c r e a s e i n OE (0,210+0.017 t o 0.30020,025 L/min/kg; p<0,005) which was n o t s u s t a i n e d , v e n t i l a t i o n decreasing t o 0,224 20,028 by 10 min of hypoxia. VT i n c r e a s e d from 3,820.2 mllkg t o 5.0'0,4 (p<0.005) and then decreased t o 3,9'0.2.
Frequency in-c r e r s e d from 56'4.0 breathslmin t o 6323 (p<0.02) and then decreased t o 5525, The changes i n I E M G D~X~ followed those i n vE0 K i t t e n s s t u d i e d b e f o r e 7 days of l i f e had a more pronounced dec r e a s e i n v e n t i l a t o r y output a t 10 min of hypoxia than o l d e r k i tt e n s , Breathing p a t t e r n became i r r e g u l a r o r p e r i o d i c during hypoxia.On r e t u r n t o 21% 02 v e n t i l a t o r y output decreased a b r u p t l y due t o apnea. These r e s u l t s suggest; 1) t h e hyperventil a t o r y response t o hypoxia i n unanesthetized k i t t e n s i s not w e l l s u s t a i n e d with values a t end of hypoxia c l o s e t o c o n t r o l l e v e l s ;2) t h e b i p h a s i c response t o hypoxia i s p r i m a r i l y a f u n c t i o n of frequency; 3) younger k i t t e n s a r e l e s s a b l e t o s u s t a i n hypervent i l a t i o n than o l d e r k i t t e n s , W e s p e c u l a t e t h a t t h e l a t e f a l l i n v e n t i l a t i o n i s due t o a c e n t r a l mechanism a f f e c t i n g frequency. Arousal from q u i e t sleep (QS) i n response t o a hypoxic challenge (HC) does n o t occur i n many apnea o f infancy (AOI) p ...
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