In this freemartin case report the authors present the clinical and morphological findings of a freemartin ewe with an abnormal position of two lymph nodes. Freemartins, infertile females from mixed-sex twin pregnancies, are chimeras, having two cell populations: one of their own (XX DNA) and one from their male twin (XY DNA). Freemartins can have varying degrees of phenotypic masculinization, including, in some cases, having active male gonads and exhibiting male behaviors such as heat detection and aggressiveness. During the clinical examination of the freemartin ewe, a morphological abnormality of the vulva, the presence of scrotal sacs, and a lack of mammary tissue development were noted. On inspection of the vaginal channel, an extremely enlarged clitoris, resembling a penis, was found. The clinical evidence suggested freemartinism. After the karyotyping diagnosis confirmation, a necropsy was performed and samples were taken for histology and immunohistochemistry. There were two structures found in the scrotal sacs; however, these were found to be lymph nodes, not testicles, and this was confirmed by CD3 lymph protein coloration. On histological study, the phallic structure showed corpus cavernosum and tunica albuginea. The testicles were found retained inside the abdominal cavity, with the presence of atrophic seminiferous tubules. Although the position of the testicles in freemartins has been reported as highly variable, this is the first time, to the best of the authors' knowledge, that a case has been reported where lymph nodes have been found inside the scrotal sacs. It is possible that these were the inguinal lymph nodes, trapped inside the scrotum during fetal growth and development.
RESUMO Porções de íleo terminal foram coletados de 100 suínos com sinais de doença gastrointestinal na área metropolitana de Bucaramanga, a fim de se estudar a eficiência do diagnóstico de enteropatia proliferativa suína (PPE) pela técnica de PCR aninha (PCRa) empregando sequências específicas (primers) para L. intracellularis: 16S ARN região (270pb) e sua correlação com achados clínicos e patológicos. Todas as amostras foram processadas para se determinar a associação entre positividade por PCR, os sinais clínicos, os achados de necropsia e as lesões histológicas. Cinquenta e seis por cento das amostras foram positivas para L. intracellularis pela PCRa. Só 2% exibiram resultados positivos pela técnica Warthin-Starry. Trinta e um de 100 animais com sinais de anorexia resultaram positivos para PCRa (P>0,05). Não houve associação (P<0,05) entre diarreia e queda no crescimento, bem como associação (P<0,05) entre achados anatomopatológicos e histológicos com PCRa positivas.
Cómo citar este artículo: Rincón GM, Albarracín-Navas JH, Duarte-Rodríguez LZ. Colangiocarcinoma intrahépatico en hembra de la raza Springer Spaniel. Spei Domus. 2014;10(20):49-56. doi: http://dx.doi.org/10. 16925/sp.v10i21.921 Resumen. El colangiocarcinoma o cgc es un tumor primario intrahépatico que se caracteriza por generar clínicamente signos inespecíficos de difícil aproximación diagnóstica; la citología dirigida con ecografía o laparotomía exploratoria facilitan su análisis, pero con el agravante de que el crecimiento tumoral en la mayoría de los casos está comprometiendo en un 60% aproximadamente el tejido hepático. El diagnóstico histopatológico permite determinar el origen primario del tumor como herramienta para su identificación y pronóstico del curso de la enfermedad. Los hallazgos clínicos no indicaron insuficiencia hepática, pero sí se evidenció hipoproteinemia y ecográficamente irregularidad de la silueta hepática para el presente caso.Palabras clave: carcinoma, conductos biliares, geronte, hepáticos, neoplasia. Intrahepatic Cholangiocarcinoma in Bitches of the Springer Spaniel BreedAbstract. Cholangiocarcinoma or cgc is a intrahepatic primary tumor characterized by its generating of nonspecific signs that are difficult to diagnose. Ultrasound-guided cytology or exploratory laparotomy help analyze it, with the drawback being that in most cases the growth of the tumor is compromising approximately 60% of the liver tissue. Histopathological diagnosis allows the identification and prognosis of the disease's progress. Clinical findings did not indicate liver failure, but in this case they did show hypoproteinemia and abnormalities in liver silhouette ultrasounds.Keywords: carcinoma, bile ducts, aging, hepatic, neoplasia. Colangiocarcinoma intra-hepático na fêmea da raça Springer SpanielResumo. O Colangiocarcinoma ou cgc é um tumor primário intrahepático que se caracteriza por gerar clinicamente signos inespecíficos de difícil aproximação diagnóstica, a citologia dirigida com ecografia ou laparotomia exploratória facilita sua análise, mas com o agravante de que o crescimento tumoral na maioria dos casos está comprometendo em 60% aproximadamente o tecido hepático. O diagnóstico histopatológi-co permite determinar a origem primária do tumor como ferramentas para sua identificação e prognóstico do curso da doença. As descobertas clínicas não indicaram insuficiência hepática, mas sim se evidenciou hipoproteinemia e ecograficamente irregularidade da silueta hepática para o presente caso.
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