Summarybackground The development of a malaria vaccine remains a public health priority for sub-Saharan Africa. RTS,S/AS02A candidate malaria vaccine has been shown to be safe and immunogenic in previous studies in adults and staggered dose-escalation studies in children in The Gambia. However, genetic features and the intensity of malaria transmission may modify the safety and immune response of a vaccine.objective We carried out a phase I, double-blind randomized controlled trial in 60 children aged 1-4 in Mozambique to evaluate the safety, reactogenicity and immunogenicity of the paediatric vaccine dose (fixed 25 lg RTS,S in 0.25 ml) of RTS,S/AS02A, prior to undertaking a planned larger phase IIb proofof-concept of efficacy study in the same population.method Children were randomized to receive either RTS,S/AS02A or Engerix-B Ò vaccine. Monitoring of safety and reactogenicity included detailed clinical and laboratory analyses and assessment of adverse events (AEs).results The RTS,S/AS02A was found to be safe and well tolerated. Serious adverse events were balanced between both groups and none was related to vaccination. The frequency of adverse events reported with RTS, S/AS02A was comparable to previous studies in children. Grade 3 AEs were infrequent (one case of pain, one of fever in each group and some swelling greater than 20 mm in diameter), transient and resolved without sequelae. RTS,S/AS02A was highly immunogenic for anti-circumsporozoite protein antibody response and induced a strong anti-hepatitis-B surface antigen response.
Este estudio se realizó con el objetivo de evaluar la estructura poblacional y el estado actual de 8 especies maderables para el Chocó, donde se estableció una parcela de 50x50, donde se registraron en forma de zig zag todos los individuos con DAP≥10cm (adultos). A partir del árbol madre se midieron 15m de radio (707m2) donde se instaló una parcela circular en la cual se registraron todos los individuos mayores a 1.3 m de altura y menores a 10cm de DAP (jóvenes); siguiendo las diagonales de la primera parcela se trazaron 12 parcelas de 2m (4m2) donde se registraron todos los individuos con altura entre 0.3 y 1.30m. A nivel de especie se registraron a Hymenaea oblogifolia y Dipterix oleífera con los valores más altos de densidad, se encontró una densidad total de 19,8 ind/ha. La mayoría de los individuos se ubicaron en la clase diametrica de 30,1-40; para la clase de altura se encontró una forma de J invertida asegurado la sostenibilidad de las especies.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.