This study aims to evaluate the efficacy and safety of oxycodone hydrochloride in treating postoperative uterine contraction pain in dysmenorrhea patients undergoing negative pressure aspiration.This study is a multicenter randomized controlled clinical trial. Two hundred patients with history of moderate or severe dysmenorrhea for negative pressure aspiration were divided into 4 groups evenly (n = 50): the control group (group P, isotonic saline), the low-dose oxycodone group (group O1), the medium-dose oxycodone group (group O2), and the high-dose oxycodone group (group O 3 ). All the 4 groups were followed by slow (45-60 seconds) static push of propofol until eyelash reflex disappeared (a maximum dose of 2.5 mg/kg). Additional propofol (0.6-1 mg/kg) was added if body movement occurred during operation.The postoperative VAS scores in different groups showed that there was no statistical difference between groups P and O1, while there were statistical differences when groups O2 and O3 were compared with group P (P < .01), and when group O3 compared with O1 (P < .01). Furthermore, there was no significant differences in HR and BP among the 4 groups, but the intraoperative respiratory frequency in groups O1, O2, and O3 was significantly higher than in group P (P < .01). The SPO 2 after operation in groups O2 and O3 was higher than in group P (P < .05). There was a significant difference in the VAS ≥ 4 between group O2 or O3 and Group P (P < .01). The incidence of respiratory depression in P group was significantly higher than in O1, O2, and O3 groups (P < .01). The dilatation time and the number of dilatation bar used in group O3 is lower than that of group P and group O1 (P < .01). The difficulty of dilatation in group P was 26% as assessed by clinicians, with significant differences with groups O1, O2, and O3 (P < .01). Conclusion:Oxycodone hydrochloride injection could be safely and effectively applied to negative pressure aspiration, and a 0.08 mg/kg dose could significantly reduce postoperative uterine contraction pain of patients with dysmenorrhea.
After analyzing the long-term evolution (LTE) 1 authentication and key agreement process (EPS-AKA), its exist-2 ing security vulnerabilities are pointed out. Based on elliptic 3 curve cryptography (ECC) self-certified public keys, this paper 4 proposes an ECC self-certified authentication key agreement 5 scheme (ESC-AKA). This scheme includes the addition of a 6 trusted center (TC), which generates the public keys for the home 7 subscriber server (HSS), the mobility management entity (MME), 8 and the user equipment (UE). Three communication protocols are 9 designed, including MME/HSS registration, UE registration, and 10 UE access. A strand space model is used to carry out the formal 11 analysis, and performance and security analyses are carried out. 12 The results show that this scheme can compensate for the security 13 vulnerabilities of the original EPS-AKA scheme. It implements 14 the encrypted transmission of the international mobile subscriber 15 identity (IMSI), and realizes the mutual authentication between 16 the HSS and MME, the MME and UE, and the HSS and UE.17Because the self-certified public key cryptosystem is adopted in 18 this scheme, communication encryption is ensured, and the risk 19 of the TC simultaneously mastering the public and private keys 20 is avoided. This scheme is proven to be effective in protecting 21 the communication security of the LTE network. 22 Index Terms-LTE, EPS-AKA, self-certified public keys, 23 authentication, key agreement protocol. 24 I. INTRODUCTION 25 L ONG-TERM evolution (LTE) [1] is a new generation of 26 broadband wireless mobile communication technology, 27 and includes the use of orthogonal frequency division mul-28 tiplexing (OFDM), multiple-input multiple-output (MIMO), 29 and other advanced technologies. These technologies greatly 30 improve the data transmission speed and meet the growing 31 demands of users for the quality of multimedia services. 4G 32
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