Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpatients with liver dysfunction and 147 literature-reported cases of Heshouwu DILI were screened. A general algorithm indicated that only 22.5% (9/40) and 30.6% (45/147) of all hospitalization and literature case reports, respectively, demonstrate the high probability of DILI causality of Heshouwu. By contrast, 95% (19/20) of all cases prospectively investigated by pharmacognosy, phytochemistry, and metabolomic tests exhibited highly probable causality, including a patient who was previously incorrectly attributed and a case that was excluded from Heshouwu causality by pharmacognostic evidence. Toxin (heavy metals, pesticides, and mycotoxins) contamination was also excluded from Heshouwu DILI causality. The objectivity of these screening methods for Heshouwu DILI diagnosis addresses safety concerns regarding stilbene-containing herbal medicines and dietary supplements.
Reinforce concrete (RC) curved bridges suffered severe damages or even collapsed in the 2008 Wenchuan Earthquake. A field survey of seismic performance of RC curved bridges was examined. Damage patterns and the probable causes of RC curved bridges including Baihua bridge and ramp bridge of Huilan interchange are presented and analyzed in this paper. The main failure was pure shear failure or shear-flexural failure of the pier columns. Bearings and expansion joints damage were another common failure pattern. Lession learned from the damage of RC curved bridges in this earthquake, the recommendations on the seismic design of RC curved bridges are presented involving ductility of bridge columns, design of curved bridges, design of bearings and devices preventing girders falling down. Suggestions for the future seismic design and retrofitting of RC curved bridges are also presented in moderate to severe earthquake area.
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