We used animal models of “forced swim stress” and “chronic unpredictable stress”, and tried to reveal whether a passive coping style of high flotation behavior in forced swim stress predicts anhedonia behavior after chronic unpredictable stress, and whether the dopamine system regulates floating and anhedonia behaviors. Our results confirmed that depression-prone rats use “floating behavior” as a coping strategy in forced swim stress and more readily suffer from anhedonia during chronic unpredictable stress. Intraperitoneal injection or nucleus accumbens microinjection of the dopamine 2/3 receptor subtype agonist ropinirole reduced floating behaviors in depression-prone animals, but increased sucrose preference in rats showing anhedonia. These data indicate that floating behavior is a defensive mode that is preferred by susceptible individuals under conditions of acute stress. Simultaneously, these animals more readily experienced anhedonia under long-term stress; that is, they were more readily affected by depression. Our results suggest that dopamine 2/3 receptor subtypes in the nucleus accumbens play an important role in floating behaviors and anhedonia.
The rapid development of E-Skin has attracted researchers’
attention to portable wearable devices. However, it is a great challenge
to achieve high-output performance and high-environmental protection
simultaneously. Polyhydroxybutyrate (PHB) has excellent electron-withdrawing
ability and biodegradability, but its stretching ability is poor,
which limits its application in portable wearable devices. In this
paper, the biocompatible poly(lactide-co-caprolactone)
(PLCL) was innovatively selected to modify the properties of the PHB
electrospun membranes, and PHB/PLCL composite membranes with different
contents of PLCL were constructed. Then, the expanded polytetrafluoroethylene
(ePTFE) membranes and PHB/PLCL electrospun membranes were used as
the friction layers to construct a flexible triboelectric nanogenerator
(TENG). With the increase of PLCL contents, the elastic recovery rate
of the composite membranes increased to 68% of tension at 40% strain.
The toughness of the composite membrane was increased by 546%, which
exhibits ultratoughness and stretchable properties. Based on the ultratoughness
and high elasticity electrospun membranes with 50% PLCL, a stretchable
and large deformation sensing device was made. The PHB/PLCL-ePTFE
TENG could distinguish pingpong and badminton accurately, as well
as their various postures such as forehand, backhand, smash poses,
etc., which provided a new idea for large deformation monitoring of
TENGs.
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