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The annual cycle of extra-tropical surface air temperature is an important component of the Earth's climate system. Over the past decades, a reduced amplitude of this mode has been observed in some regions. Although attributed to anthropogenic forcing, it remains unclear when dampening of the annual cycle started. Here we use a residual series of tree-ring width and maximum latewood density from the Tibetan Plateau >4,000 m asl to reconstruct changes in temperature seasonality over the past three centuries. The new proxy evidence suggests that the onset of a decrease in summer-to-winter temperature difference over the Tibetan Plateau occurred in the 1870s. Our results imply that the influence of anthropogenic forcing on temperature seasonality might have started in the late nineteenth century, and that future human influence may further contribute to a weakening of the annual temperature cycle, with subsequent effects on ecosystem functioning and productivity.

Trust is indispensable not only for interpersonal relationships and social life, but for good quality healthcare. As manifested in the increasing violence and tension in patient-physician relationships, China has been experiencing a widespread and profound crisis of patient-physician trust. And globally, the crisis of trust is an issue that every society, either developing or developed, has to face in one way or another. Yet, in spite of some pioneering works, the subject of patient-physician trust and mistrust --a crucial matter in healthcare especially because there are numerous ethical implications --has largely been marginalized in bioethics as a global discourse. Drawing lessons as well as inspirations from China, this paper demonstrates the necessity of a trust-oriented bioethics and presents some key theoretical, methodological and philosophical elements of such a bioethics. A trust-oriented bioethics moves beyond the current dominant bioethical paradigms through putting the subject of trust and mistrust in the central agenda of the field, learning from the social sciences, and reviving indigenous moral resources.In order for global bioethics to claim its relevance to the things that truly matter in social life and healthcare, trust should be as vital as such central norms like autonomy and justice and can serve as a potent theoretical framework. KEW WORDSChina, trust, patient-physician relationship, healthcare, trust-oriented bioethics, global bioethics 2 The theme of this special issue is "Rebuilding patient-physician trust in China, Developing a trust-oriented bioethics." Utilising a methodology that integrates anthropological and sociological inquiry with ethical analysis, the previous articles have investigated the phenomenon and sources of patient-physician mistrust and the mechanisms required to rebuild a trust in the healthcare system in mainland China. Drawing lessons as well as inspirations from China, in this paper we argue for the necessity of a trust-oriented bioethics and outline the theoretical and methodological foundations of such a bioethics. By so doing, this paper addresses specifically the second main aim of this thematic issue."People cannot stand without trust," as Confucius asserted 2600 years ago in one of his best-known statements, recorded by his disciples in Lunyu (The Analects) (Book XII: 7). Among other things, this means that if trust is absent, neither individual life nor local communities and the wider society can thrive or even survive. The central thesis of this paper (and the entire thematic issue) is that, to paraphrase Confucius, medicine cannot stand without mutual trust between patients and their relatives, on the one side, and health professionals and institutions on the other. And neither can bioethics in China and around the globe stand upright without placing trust in its central agenda. PATIENT-PHYSICIAN MISTRUST IN CHINA: CONSEQUENCES AND CONTEXTChina, the world's most populous country where more than 1.3 billion people live, has been experiencing an e...

Based on temperature data from 79 meteorological stations, we estimate the warming rate by season on the Tibetan Plateau (TP) during 1984–2013. The warming rate was spatially heterogeneous across seasons over the past 30 years. The northern TP (NTP) experienced more warming than the southern TP (STP) (divided near 33°N) in all seasons. The greatest north-south difference in warming was 0.70 ± 0.11 °C for summer (June-August), while the smallest difference was 0.27 ± 0.14 °C for the cold season (November-April). Such seasonal and spatial heterogeneity in the warming rate is consistent with the seasonal precipitation patterns of the NTP and the STP. One possible cause for this phenomenon is that more precipitation occurs in the STP than in the NTP (especially for summer), accompanied by more low cloud cover, which may have slowed the warming rate. Our results imply that dry regions on the TP will possibly experience greater temperature increase than wet regions under future global warming, and this will be more prominent in summer.

Large volcanic eruptions may cause abrupt summer cooling over large parts of the globe. However, no comparable imprint has been found on the Tibetan Plateau (TP). Here, we introduce a 400-yr-long temperature-sensitive network of 17 tree-ring maximum latewood density sites from the TP that demonstrates that the effects of tropical eruptions on the TP are generally greater than those of extratropical eruptions. Moreover, we found that large tropical eruptions accompanied by subsequent El Niño events caused less summer cooling than those that occurred without El Niño association. Superposed epoch analysis (SEA) based on 27 events, including 14 tropical eruptions and 13 extratropical eruptions, shows that the summer cooling driven by extratropical eruptions is insignificant on the TP, while significant summer temperature decreases occur subsequent to tropical eruptions. Further analysis of the TP August–September temperature responses reveals a significant postvolcanic cooling only when no El Niño event occurred. However, there is no such cooling for all other situations, that is, tropical eruptions together with a subsequent El Niño event, as well as extratropical eruptions regardless of the occurrence of an El Niño event. The averaged August–September temperature deviation ( Tdev) following 10 large tropical eruptions without a subsequent El Niño event is up to −0.48° ± 0.19°C (with respect to the preceding 5-yr mean), whereas the temperature deviation following 4 large tropical eruptions with an El Niño association is approximately 0.23° ± 0.16°C. These results indicate a mitigation effect of El Niño events on the TP temperature response to large tropical eruptions. The possible mechanism is that El Niño events can weaken the Indian summer monsoon with a subsequent decrease in rainfall and cooling effect, which may lead to a relatively high temperature on the TP, one of the regions affected by the Indian summer monsoon.

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Electron tomography (ET) plays an important role in studying in situ cell ultrastructure in three-dimensional space. Due to limited tilt angles, ET reconstruction always suffers from the “missing wedge” problem. With a validation procedure, iterative compressed-sensing optimized NUFFT reconstruction (ICON) demonstrates its power in the restoration of validated missing information for low SNR biological ET dataset. However, the huge computational demand has become a major problem for the application of ICON. In this work, we analyzed the framework of ICON and classified the operations of major steps of ICON reconstruction into three types. Accordingly, we designed parallel strategies and implemented them on graphics processing units (GPU) to generate a parallel program ICON-GPU. With high accuracy, ICON-GPU has a great acceleration compared to its CPU version, up to 83.7×, greatly relieving ICON’s dependence on computing resource.

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