The antigens of the HLA system represent a distinctive marker in identifying racial and population groups by means of an anthropological and relational characterization. Building a database is beneficial to forensic identification, to implement transplant programs and to determine a predisposition to certain illnesses. We performed the HLA class I serotyping on the antigens on HLA A and HLA B loci for 1250 unrelated individuals from the Romanian population; based on this we calculated the allelic frequency. The most frequent antigen on the HLA A locus was HLA A2, and on the HLA B locus was HLA B35. We subsequently compared the results we obtained for the Romanian population with similar data from several Balkan populations.
We report a case of Prinzmetal angina as inaugural manifestation of coronary disease, in a young adult male patient, recently started on anagrelide for essential thrombocythemia. Moderate proximal left anterior descendent coronary artery stenosis was documented by angiography, and interventional or surgical revascularization has been discussed. Patient’s option was for medical therapy alone. Anagrelide was temporarily withdrawn and rechallenged uneventfully after a couple of months and clinical evolution is good at four years follow-up. The mechanism by which anagrelide could induce coronary spasm and ischemia remains to be clarified.
We present a case of severe thromboembolic pulmonary hypertension in a patient with history of recurrent deep vein thrombosis and pulmonary restrictive disease due to pulmonary and vertebral tuberculosis in young adulthood. He was considered not eligible in the National Program for Primary Pulmonary Hypertension, being referred for thoracic surgery, but he was considered unfit for thrombendarterectomy. Despite guidelines, we administered him specific medical therapy (phosphodiesterase-5 inhibitors and endothelin receptor antagonists). His clinical evolution was satisfactory, with increasing effort tolerance and decreasing need for ambulatory oxigenotherapy.Keywords. Pulmonary thromboembolic hypertension, thrombendarterectomy, phosphodiesterase-5 inhibitors, endothelin receptor antagonists. Irinel Raluca ParepaUniversity "Ovidius" of Constanţa, Faculty of Medicine, Department of Cardiology Aleea Universităţii 1, 900470, Constanța email : irinel_parepa@yahoo.com 10.1515/arsm-2017-0017 ARS Medica Tomitana -2017 2(23): 94 -98 Case ReportWe present the case of a 64 years old male patient, with history of right femuro-popliteal deep vein thrombosis and recurrent pulmonary thromboembolism. He experienced his first pulmonary embolism 3 years ago and repeated a new episode after about 6 months, when we estimated at echocardiography a value of the systolic pressure in the pulmonary artery of 70 mmHg, indicating severe pulmonary hypertension.Due to the recurrence of the pulmonary thromboembolism, at that time we performed investigations aiming to highlight some of the associated thromboembolic risk factors: the thrombophilic profile was normal, tumoral markers, abdominal and pelvic CT were negative for malignant diseases. He had no family antecedents of clinical manifestations of thromboembolic diseases.After a period of about 6 months with minimal symptoms under oral anticoagulant and diuretic treatment, the patient returns in the Cardiology Clinic with decompensated right heart failure (inferior limbs edema, hepatomegaly with turgid jugulars), respiratory insufficiency (spontaneous Sp02 = 88%) and systemic hypotension (blood pressure = 90/60mmHg, equal on both arms). Clinical examination also revealed severe decreased body mass index (16,6kg/m2) and diastolic murmur in the pulmonary area. On ultrasound we detected worsened pulmonary pressures (systolic
The rapid implementation of stents in standard practice and expansion of the indication for their utilization also introduced a new problem: in-stent restenosis. Management of patients with restenosis after stent implantation is still considered an important clinical problem. Although balloon angioplasty is still one of the prefered strategies that provide satisfactory results and a low incidence of complication, repeat stenting with “drug eluting” stents or “drug balloon” angioplasty become a very atractive methods of treatment for selected lesions and patients.
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