Parkinson’s disease (PD) is a common
neurodegenerative
disorder caused by dopaminergic neuron progressive degeneration. Inhibition
of microglial activation may contribute to the treatment and prevention
of PD. Plantamajoside (PMS) is a natural compound extracted from plantain
seeds. It has a wide range of biological activities, including anti-inflammatory,
antioxidative, as well as antitumor effects. However, its possible
effects on PD are still unclear. In this study, lipopolysaccharide
(LPS) was first injected into the right midbrain substantia nigra
(SN) of male C57BL/6 mice to establish the PD mouse model. We found
that PMS improved LPS-induced behavioral dysfunction in PD mice. PMS
attenuated LPS-induced SN injury in PD mice. PMS could suppress LPS-induced
microglial overactivation in PD mice. In addition, MS inhibited LPS-induced
activation of the HDAC2/MAPK pathway in PD mice and BV-2 cells. It
further revealed that PMS alleviated microglia polarization by inhibiting
HDAC2. The limitation of this study was the lack of experiments for
investigating the further molecular mechanism and in vivo animal validation,
which needs to be further confirmed in the future. Collectively, our
data suggested that PMS could serve as a promising drug for PD.
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