Currently, antibiotic resistance and cancer are two of the most important public health problems killing more than ∼1.5 million people annually, showing that antibiotics and current chemotherapeutics are not as effective as they were in the past. Nanotechnology is presented here as a potential solution. However, current protocols for the traditional physicochemical synthesis of nanomaterials are not free of environmental and social drawbacks, often involving the use of toxic catalysts. This article shows the production of pure naked selenium nanoparticles (SeNPs) by a novel green process called pulsed laser ablation in liquids (PLAL). After the first set of irradiations, another set was performed to reduce the size below 100 nm, which resulted in a colloidal solution of spherical SeNPs with two main populations having sizes around ∼80 and ∼10 nm. The particles after the second set of irradiations also showed higher colloidal stability. SeNPs showed a dose-dependent antibacterial effect toward both standard and antibioticresistant phenotypes of Gram-negative and Gram-positive bacteria at a range of concentrations between 0.05 and 25 ppm. Besides, the SeNPs showed a low cytotoxic effect when cultured with human dermal fibroblasts cells at a range of concentrations up to 1 ppm while showing an anticancer effect toward human melanoma and glioblastoma cells at the same concentration range. This article therefore introduces the possibility of using totally naked SeNPs synthesized by a new PLAL protocol as a novel and efficient nanoparticle fabrication process for biomedical applications.
Cancer and antimicrobial resistance to antibiotics are two of the most worrying healthcare concerns that humanity is facing nowadays. Some of the most promising solutions for these healthcare problems may come from nanomedicine. While the traditional synthesis of nanomaterials is often accompanied by drawbacks such as high cost or the production of toxic by-products, green nanotechnology has been presented as a suitable solution to overcome such challenges. In this work, an approach for the synthesis of tellurium (Te) nanostructures in aqueous media has been developed using aloe vera (AV) extracts as a unique reducing and capping agent. Te-based nanoparticles (AV-TeNPs), with sizes between 20 and 60 nm, were characterized in terms of physicochemical properties and tested for potential biomedical applications. A significant decay in bacterial growth after 24 h was achieved for both Methicillin-resistant Staphylococcus aureus and multidrug-resistant Escherichia coli at a relative low concentration of 5 µg/mL, while there was no cytotoxicity towards human dermal fibroblasts after 3 days of treatment. AV-TeNPs also showed anticancer properties up to 72 h within a range of concentrations between 5 and 100 µg/mL. Consequently, here, we present a novel and green approach to produce Te-based nanostructures with potential biomedical applications, especially for antibacterial and anticancer applications.
Bismuth oxide is an important bismuth compound having applications in electronics, photo-catalysis and medicine. At the nanoscale, bismuth oxide experiences a variety of new physico-chemical properties because of its increased...
Gold has always fascinated
humans, occupying an important functional
and symbolic role in civilization. In earlier times, gold was predominantly
used in jewelry; today, this noble metal’s surface properties
are taken advantage of in catalysis and plasmonics. In this article,
the plasmon resonance of gold dumbbell nanorods is investigated. This
unusual morphology was obtained by a seed-mediated growth method.
The concentration of chemical precursors such as cetyltrimethylammonium
bromide and silver nitrate plays a significant role in controlling
the shape of the nanorods. Indeed, the aspect ratio of dumbbell nanostructures
was varied from 2.6 to 4. UV–visible absorption spectra revealed
a shift of the longitudinal surface plasmon resonance peak from 669
to 789 nm. Having the plasmon resonance in the near infrared region
helps to use those nanostructures as photothermal agents.
Selenium and tellurium are both energy critical elements as defined by the American Physical Society and the Materials Research Society. When mixed together, both elements form an alloy. The size-...
Bismuth antimonide is an important material in nanoelectronics as a topological insulator and thermoelectric material. However, some of its thermal properties are still mostly unknown at the nanoscale. The goal of this paper is to fill this gap in knowledge and provide the phase diagram of bismuth antimonide at small sizes for different types of morphologies like the sphere, rod, wire, and film. By using nanothermodynamics concepts, a surface segregation index is newly defined to easily determine which chemical element segregates preferentially to the surface. In bismuth antimonide nanostructures, bismuth is predicted to be the pnictogen element segregating naturally to the surface of the alloy. Moreover, the chemical ordering (alloy, core−shell, and Janus) of bismuth antimonide is provided as a function of size, temperature, and composition. Finally, the miscible region where bismuth and antimony forms a randomly mixed alloy is found to shrink considerably when the size of the nanostructure is reduced, whatever the considered shape is. This confirms that miscibility is not enhanced at the nanoscale but phase separation is.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.